{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM813068": {"GENDER": "female", "AGE": 28}}, {"GSM813069": {"GENDER": "female", "AGE": 80}}, {"GSM813070": {"GENDER": "male", "AGE": 79}}, {"GSM81307": {"GENDER": "female", "AGE": 46}}], "id": 4255, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Recently, the bone marrow (BM) has been shown to play a key role in regulating the survival and function of memory T cells. However, the...", "geo_gse_id": "E-GEOD-32725", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["bone", "bone marrow", "cell", "line", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "the-impact-of-aging-on-memory-t-cell-phenotype-and", "geo_id_plat": "E-GEOD-32725_A-AFFY-44", "name": "The impact of aging on memory T cell phenotype and function in the human bone marrow", "created": "Sep.16, 2014", "summary": "Recently, the bone marrow (BM) has been shown to play a key role in regulating the survival and function of memory T cells. However, the impact of aging on these processes has not yet been studied. We demonstrate that the number of CD4+ and CD8+ T cells in the BM is maintained during aging. However, the composition of the T cell pool in the aged BM is altered with a decline of na\u00efve and an increase in effector-memory T cells. In contrast to the peripheral blood (PB), a highly activated CD8+CD28\u2013 T cell population, which lacks the late differentiation marker CD57, accumulates in the BM of elderly persons. IL-6 and IL-15, which are both increased in the aged BM, efficiently induce the activation, proliferation and differentiation of CD8+ T cell in vitro, highlighting a role of these cytokines in the age-dependent accumulation of highly activated CD8+CD28\u2013 T cells in the BM. Yet, these age-related changes do not impair the maintenance of a high number of polyfunctional memory CD4+ and CD8+ T cells in the BM of elderly persons. In summary, aging leads to the accumulation of a highly activated CD8+CD28\u2013 T cell population in the BM, which is driven by the age-related increase of IL-6 and IL-15. Despite these changes, the aged BM is a rich source of polyfunctional memory T cells and may thus represent an important line of defense to fight recurrent infections in old age. A total of 4 samples (bone marrow mononuclear cells) were analyzed (2 young and 2 elderly persons)", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32725", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32725/samples/"}