{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM811004": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 90.0, "AJCC STAGE": "2B"}}, {"GSM811005": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 90.0, "AJCC STAGE": "1B"}}, {"GSM811006": {"GRADE": 1.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 80.0, "AJCC STAGE": "2A"}}, {"GSM811007": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 80.0, "AJCC STAGE": "2B"}}, {"GSM811007": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 80.0, "AJCC STAGE": "2B"}}, {"GSM811009": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 80.0, "AJCC STAGE": "2B"}}, {"GSM811010": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 75.0, "AJCC STAGE": "1B"}}, {"GSM8110": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 75.0, "AJCC STAGE": "2B"}}, {"GSM8110": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 75.0, "AJCC STAGE": "2B"}}, {"GSM811013": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 70.0, "AJCC STAGE": "2B"}}, {"GSM811014": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 60.0, "AJCC STAGE": "2B"}}, {"GSM811015": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 60.0, "AJCC STAGE": "2A"}}, {"GSM811016": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 60.0, "AJCC STAGE": "2B"}}, {"GSM811015": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 60.0, "AJCC STAGE": "2A"}}, {"GSM811018": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 50.0, "AJCC STAGE": "2A"}}, {"GSM811019": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 50.0, "AJCC STAGE": "2B"}}, {"GSM811019": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 50.0, "AJCC STAGE": "2B"}}, {"GSM81102": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 50.0, "AJCC STAGE": "2B"}}, {"GSM811022": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 45.0, "AJCC STAGE": "2A"}}, {"GSM811023": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 40.0, "AJCC STAGE": "2B"}}, {"GSM811023": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 40.0, "AJCC STAGE": "2B"}}, {"GSM811025": {"GRADE": 3.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 35.0, "AJCC STAGE": "2B"}}, {"GSM811026": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 35.0, "AJCC STAGE": "2B"}}, {"GSM811026": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 35.0, "AJCC STAGE": "2B"}}, {"GSM811028": {"GRADE": 2.0, "DISEASE STATUS": "pancreatic cancer", "TUMOR CONTENT": 35.0, "AJCC STAGE": "2A"}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}, {"GSM811029": {"GRADE": NaN, "DISEASE STATUS": "non-malignant pancreas", "TUMOR CONTENT": NaN, "AJCC STAGE": NaN}}], "id": 4251, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "To perform an integrative profile of human pancreatic cancer (PDAC) to identify prognosis-significant genes and their related pathways. A...", "geo_gse_id": "E-GEOD-32676", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 32, "tags": ["cancer", "cell", "composite", "disease", "genome", "pancreas", "pancreatic cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "integrative-survival-based-molecular-profiling-of", "geo_id_plat": "E-GEOD-32676_A-AFFY-44", "name": "Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer [mRNA]", "created": "Sep.16, 2014", "summary": "To perform an integrative profile of human pancreatic cancer (PDAC) to identify prognosis-significant genes and their related pathways. A concordant survival-based whole genome in silico array analysis of DNA copy number, and mRNA & micro RNA (miRNA) expression in 25 early stage PDAC was performed. A novel composite score simultaneously integrated gene expression with regulatory mechanisms to identify the signature genes with the most levels of prognosis-significant evidence. The predominant signaling pathways were determined via a pathway-based approach. Independent patient cohorts (n= 150 and 42) were then used as in vitro validation of the array findings. We find that EGFR, SRC signaling, and PI3K/AKT pathway activation are strongly linked to clinical disease progression. Furthermore, we identify two discrete subsets of pancreatic tumors characterized by either SRC or PI3K/AKT signaling that may dictate variable responses to targeted therapy. 42 human PDAC tumors and 7 non-malignant pancreas samples snap-frozen at the time of surgery were chosen. Representative H&E sections of each were evaluated by a practicing gastrointestinal pathologist to confirm diagnosis and determine relative percentage of malignant cells. Samples with tumor cell content >30% were chosen for final multi-platform analysis (N=25). Human pancreatic samples were profiled on Affymetrix HGU133 Plus 2 arrays per manufacturer's instructions.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32676", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32676/samples/"}