ArrayExpress Uploaderarrayexpress_sidhumannormalnegativenot specifiednormalnegativenot specifiednormalnegativenot specifiednormalnegativenot specifiedbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)negativeyesbone metastases (CRPC)positiveyeslocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancernegativenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancerpositivenolocalized prostate cancernegativeno128003We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle,...E-GEOD-32269/profile/8773/arrayexpressuploader355androgenbonebone marrowcancercellhormonelcmpcaprostateprostate cancerDec.12, 2014Falseexpression-data-for-primary-localized-prostate-canE-GEOD-32269_A-AFFY-33Expression data for primary localized prostate cancer versus castration-resistant bone metastatic prostate cancerJun.18, 2014We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle, proliferation, DNA synthesis, and androgen metablism are significantly increased in CRPC group. The expression of AR-stimulated genes were partially reactivated. TMPRSS2-ERG fusion status was determined for the samples by PCR. The expression of ERG was highly increased in fusion positive versus negative. 120 snap-frozen CT-guided bone marrow biopsies from patients with castration-resistant prostate cancer were collected as a source of material. 29 independent biopsies containing mostly tumor were identified as CRPC group through carefully microscopical examination. 4 samples containing no tumor were identified as normal bone marrow group. Primary tumor was isolated by LCM from frozen biopsies of hormone-naive patients. 22 samples were selected as primary PCa group.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32269http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32269/samples/