{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM799522": {"METASTASIS": "normal", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "not specified"}}, {"GSM799522": {"METASTASIS": "normal", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "not specified"}}, {"GSM799522": {"METASTASIS": "normal", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "not specified"}}, {"GSM799522": {"METASTASIS": "normal", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "not specified"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799517": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799518": {"METASTASIS": "bone metastases (CRPC)", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "yes"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799489": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "positive", "ANDROGEN DEPRIVATION": "no"}}, {"GSM799484": {"METASTASIS": "localized prostate cancer", "TMPRSS2-ERG": "negative", "ANDROGEN DEPRIVATION": "no"}}], "id": 1280, "pop_total": 0, "platform": 3, "summary_wrapped": "We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle,...", "geo_gse_id": "E-GEOD-32269", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 55, "tags": ["androgen", "bone", "bone marrow", "cancer", "cell", "hormone", "lcm", "pca", "prostate", "prostate cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-for-primary-localized-prostate-can", "geo_id_plat": "E-GEOD-32269_A-AFFY-33", "name": "Expression data for primary localized prostate cancer versus castration-resistant bone metastatic prostate cancer", "created": "Jun.18, 2014", "summary": "We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle, proliferation, DNA synthesis, and androgen metablism are significantly increased in CRPC group. The expression of AR-stimulated genes were partially reactivated. TMPRSS2-ERG fusion status was determined for the samples by PCR. The expression of ERG was highly increased in fusion positive versus negative. 120 snap-frozen CT-guided bone marrow biopsies from patients with castration-resistant prostate cancer were collected as a source of material. 29 independent biopsies containing mostly tumor were identified as CRPC group through carefully microscopical examination. 4 samples containing no tumor were identified as normal bone marrow group. Primary tumor was isolated by LCM from frozen biopsies of hormone-naive patients. 22 samples were selected as primary PCa group.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32269", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-32269/samples/"}