ArrayExpress Uploader0humanEJ1Human bladder carcinoma, fast growing tumourNHUNormal human urothelial cell line, moderate growthRT112Human bladder carcinoma, relatively fast growing tumour4222arrayexpress_sid4To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and...E-GEOD-31864/profile/8773/arrayexpressuploader23cancercellcytosinehistonelineurotheliumDec.12, 2014Falseepigenome-profiling-of-repressive-histone-modificaE-GEOD-31864_A-AFFY-44Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cellsSep.16, 2014To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression. Two repressive histone modifications (H3K9m3 and H3K27m3) , cytosine methylation and gene expression were compared between normal human urothelial cell line (NHU) and malignant urothelial cells (EJ and RT112).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31864http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31864/samples/