ArrayExpress Uploader0humanMDA-MB231Knock-downMDA-MB231Control (scrambled siRNA)MDA-MB231Knock-downMDA-MB231Control (scrambled siRNA)MDA-MB231Knock-downMDA-MB231Control (scrambled siRNA)MDA-MB231Knock-downMDA-MB231Control (scrambled siRNA)MCF-7Knock-downMCF-7Control (scrambled siRNA)MCF-7Knock-downMCF-7Control (scrambled siRNA)MCF-7Knock-downMCF-7Control (scrambled siRNA)MCF-7Knock-downMCF-7Control (scrambled siRNA)MCF-7Over-expressedMCF-7Over-expressedMCF-7Over-expressedMCF-7Control (empty vector)MCF-7Over-expressedMCF-7Over-expressedMCF-7Over-expressedMCF-7Control (empty vector)MCF-7Over-expressedMCF-7Over-expressedMCF-7Over-expressedMCF-7Control (empty vector)4221arrayexpress_sid4By survival analysis of breast cancer patients, JMJD6 was found to be significantly associated with poor prognosis. Over-expression and...E-GEOD-31782/profile/8773/arrayexpressuploader228breastbreast cancercancercellDec.12, 2014Falseknock-down-and-over-expression-of-jmjd6-in-mcf-7-aE-GEOD-31782_A-AFFY-44Knock-down and Over-expression of JMJD6 in MCF-7 and/or MDA-MB231Sep.16, 2014By survival analysis of breast cancer patients, JMJD6 was found to be significantly associated with poor prognosis. Over-expression and knock-down of JMJD6 in breast cancer cell lines suggested a role in proliferation. In order to study the transcriptional events that occur following JMJD6 expression changes, siRNA-mediated knock-down of JMJD6 was performed in MCF-7 and MDA-MB231 and stable over-expression of JMJD6 was performed in MCF-7. There are 2 different siRNA-mediated knock-downs of JMJD6 with 2 biological replicates in MCF-7 and MDA-MB231; 3 clones of JMJD6 over-expression with 3 biological replicates in MCF-7. The control for the knock-downs is scrambled siRNA-treated MCF-7 and MDA-MB231 and the control for JMJD6 over-expression is empty vector over-expression in MCF-7.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31782http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31782/samples/