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No...", "geo_gse_id": "E-GEOD-31773", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 8, "sample_count": 40, "tags": ["asthma", "cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "comparison-of-mrna-expression-in-circulating-t-cel", "geo_id_plat": "E-GEOD-31773_A-AFFY-44", "name": "Comparison of mRNA expression in circulating T-cells from patients with severe asthma", "created": "Sep.16, 2014", "summary": "Comparison of mRNA expression showed widespread changes in the circulating CD8+ but not CD4+ T-cells from patients with severe asthma. No changes were observed in the CD4+ and CD8+ T-cells in non-severe asthmatics versus healthy controls. Bioinformatics analysis showed that the changes in CD8+ T-cell mRNA expression were associated with multiple pathways involved in T-cell activation. As with mRNAs, we also observed widespread changes in expression of non-coding RNA species including natural antisense, pseudogenes, intronic long ncRNAs and long intergenic long ncRNAs in CD8+ T-cells from severe asthmatics. Measurement of the miRNA expression profile showed selective down-regulation of miR-28-5p in CD8+ T-cells and reduction of miR-146a and miR-146b in both CD4+ and CD8+ T-cells. mRNA samples were collected from circulating CD4+ and CD8+ T-cells from healthy donors as well as donors with severe and non-severe asthma.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31773", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31773/samples/"}