{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM786802": {"STRAIN": "B6"}}, {"GSM786802": {"STRAIN": "B6"}}, {"GSM786802": {"STRAIN": "B6"}}, {"GSM786802": {"STRAIN": "B6"}}, {"GSM786802": {"STRAIN": "B6"}}, {"GSM786807": {"STRAIN": "B6.Sle1c2"}}, {"GSM786807": {"STRAIN": "B6.Sle1c2"}}, {"GSM786807": {"STRAIN": "B6.Sle1c2"}}, {"GSM786807": {"STRAIN": "B6.Sle1c2"}}, {"GSM786807": {"STRAIN": "B6.Sle1c2"}}], "id": 6600, "pop_total": 0, "platform": 6, "summary_wrapped": "Sle1c is a sublocus of the NZM2410-derived Sle1 major susceptibility locus.  We have previously shown that Sle1c contributes to lupus...", "geo_gse_id": "E-GEOD-31702", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 10, "tags": ["cell", "disease", "lupus"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-31702_A-AFFY-45", "slug": "cd4-t-cell-gene-expression-in-b6-vs-b6sle1c2-mice", "geo_gds_id": "", "name": "CD4+ T cell gene expression in B6 vs B6.Sle1c2 mice", "created": "Nov.11, 2014", "summary": "Sle1c is a sublocus of the NZM2410-derived Sle1 major susceptibility locus.  We have previously shown that Sle1c contributes to lupus pathogenesis by conferring CD4+ T cell-intrinsic hyperactivation and increased susceptibility to chronic graft-versus-host disease (cGVHD) that mapped to the centromeric portion of the locus.  In this study, we have refined the centromeric sublocus to a 675Kb interval, termed Sle1c2.  Recombinant congenic strains expressing Sle1c2 exhibited a T cell-intrinsic CD4+ T cell hyperactivation and cGVHD susceptibility, similar to mice with the parental Sle1c. We performed a microarray analysis on CD4+ T cells to gain insights into the transcriptional programs that regulate the hyperactivation conferred by Sle1c2. CD4+ T cell cDNA was prepared from spenocytes from 5 mice from each strain and B6.Sle1c2 gene expression was compared to B6 gene expresion.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31702", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31702/samples/"}