ArrayExpress Uploader08573AChE-SnaïvePre-Frontal CortexAChE-SnaïvePre-Frontal CortexFVB/NnaïvePre-Frontal CortexFVB/NnaïvePre-Frontal CortexAChE-RnaïvePre-Frontal CortexAChE-RnaïvePre-Frontal CortexFVB/NMPTPPre-Frontal CortexFVB/NMPTPPre-Frontal CortexAChE-RMPTPPre-Frontal CortexAChE-RMPTPPre-Frontal CortexAChE-SMPTPPre-Frontal CortexAChE-SMPTPPre-Frontal CortexFVB/Nnaïvecaudate putamenFVB/Nnaïvecaudate putamenFVB/NMPTPcaudate putamenFVB/NMPTPcaudate putamenAChE-Snaïvecaudate putamenAChE-Snaïvecaudate putamenAChE-SMPTPcaudate putamenAChE-SMPTPcaudate putamenAChE-Rnaïvecaudate putamenAChE-Rnaïvecaudate putamenAChE-RMPTPcaudate putamenFVB/NnaïvePre-Frontal CortexFVB/NnaïvePre-Frontal CortexAChE-SnaïvePre-Frontal CortexAChE-SnaïvePre-Frontal CortexAChE-RnaïvePre-Frontal CortexAChE-RnaïvePre-Frontal Cortexarrayexpress_sid8PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the...22198569E-GEOD-31458/profile/8773/arrayexpressuploader329braincortexdiseasefrontalneurodegenerative diseaseparkinson's diseaseputamenDec.12, 2014Falseexpression-data-from-naive-and-mptp-exposed-cholinE-GEOD-31458_A-AFFY-36Expression data from naïve and MPTP-exposed cholinergic transgenic miceNov.24, 2014PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the first drugs used for symptomatic treatment of PD. Of note, MPTP intoxication is a model of choice for symptomatic neuroprotective therapies since it have been quite predictive. Mice were exposed to the dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), with or without the protective acetylcholinesterase (AChE-R) variant. Transgenic AChE-S (the synaptic variant), AChE-R (the shorter, protective variant) and FVB/N control mice were included in this study. Two brain regions were examined: the pre-frontal cortex (PFC) and the striatal caudate-putamen (CPu). Each condition (i.e brain region and transgenic variant) was examined on both naive and MPTP-exposed mice. 29 microarrays including hybridizations of control FVB/N PFC, control FVB/N CPu,control S transgenics PFC, control S transgenics CPu, control R transgenics PFC, control R transgenice CPu, MPTP FVB/N PFC, MPTP FVB/N CPu, MPTP S transgenics PFC, MPTP S transgenics CPu, MPTP R transgenics PFC and MPTP R transgenice CPu mRNA.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31458mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31458/samples/