{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 8573, "factors": [{"GSM781740": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781740": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781742": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781742": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781744": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781744": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781746": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781746": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781748": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781748": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781750": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781750": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "MPTP", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781752": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781752": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781754": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "MPTP", "ORGANISM PART": "caudate putamen"}}, {"GSM781754": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "MPTP", "ORGANISM PART": "caudate putamen"}}, {"GSM781756": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781756": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781758": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "MPTP", "ORGANISM PART": "caudate putamen"}}, {"GSM781758": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "MPTP", "ORGANISM PART": "caudate putamen"}}, {"GSM781760": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781760": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "caudate putamen"}}, {"GSM781762": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "MPTP", "ORGANISM PART": "caudate putamen"}}, {"GSM781742": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781742": {"TRANSGENIC VARIANT": "FVB/N", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781740": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781740": {"TRANSGENIC VARIANT": "AChE-S", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781744": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}, {"GSM781744": {"TRANSGENIC VARIANT": "AChE-R", "TREATMENT": "na\u00efve", "ORGANISM PART": "Pre-Frontal Cortex"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "PD  is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the...", "pubmed_id": 22198569, "geo_gse_id": "E-GEOD-31458", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 29, "tags": ["brain", "cortex", "disease", "frontal", "neurodegenerative disease", "parkinson's disease", "putamen"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-naive-and-mptp-exposed-cholin", "geo_id_plat": "E-GEOD-31458_A-AFFY-36", "name": "Expression data from na\u00efve and MPTP-exposed cholinergic transgenic mice", "created": "Nov.24, 2014", "summary": "PD  is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology.  The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the first drugs used for symptomatic treatment of PD. Of note, MPTP intoxication is a model of choice for symptomatic neuroprotective therapies since it have been quite predictive. Mice were exposed to the dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), with or without the protective acetylcholinesterase (AChE-R) variant. Transgenic AChE-S (the synaptic variant), AChE-R (the shorter, protective variant) and FVB/N control mice were included in this study. Two brain regions were examined: the pre-frontal cortex (PFC) and the striatal caudate-putamen (CPu). Each condition (i.e brain region and transgenic variant) was examined on both naive and MPTP-exposed mice. 29 microarrays including hybridizations of control FVB/N PFC, control FVB/N CPu,control S transgenics PFC, control S transgenics CPu, control R transgenics PFC, control R transgenice CPu,  MPTP FVB/N PFC, MPTP FVB/N CPu, MPTP S transgenics PFC, MPTP S transgenics CPu, MPTP R transgenics PFC and MPTP R transgenice CPu mRNA.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31458", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31458/samples/"}