ArrayExpress Uploader0658720wC57/B6wild type20wC57/B6wild type20wC57/B6wild type20wC57/B6wild type20wC57/B6wild type48wC57/B6wild type48wC57/B6wild type48wC57/B6wild type48wC57/B6wild type20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice20wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic mice48wPdgf-c TgPDGF-C transgenic micearrayexpress_sid6Over expression of PDGF-C in mouse liver resulted in the progression of hepatic fibrosis, steatosis and the development of HCC; this...22651928E-GEOD-31431/profile/8773/arrayexpressuploader334basalhccliverDec.12, 2014Falseserial-gene-expression-profiling-in-the-liver-of-pE-GEOD-31431_A-AFFY-45Serial gene expression profiling in the liver of Pdgf-c Tg mice that developed hepatic fibrosis and tumorsNov.11, 2014Over expression of PDGF-C in mouse liver resulted in the progression of hepatic fibrosis, steatosis and the development of HCC; this mouse model closely resembles the human HCC that is frequently associated with hepatic fibrosis. Peretinoin (generic name; code, NIK-333), developed by the Kowa Company, (Tokyo, Japan), is an oral acyclic retinoid (ACR) with a vitamin A-like structure that targets the retinoid nuclear receptor. Peretinoin effectively inhibits the progression of hepatic fibrosis and tumors in Pdgf-c Tg mice. Gene expression profiling was evaluated during the progression of hepatic fibrosis and tumors. After weaning at week 4, Pdgf-c Tg or non-transgenic WT mice were fed a basal diet or a diet containing+0.06% peretinoin respectively. At week 20, mice were sacrificed for the analysis of progression of hepatic fibrosis. At week 48, mice were sacrificed for the analysis of the development of hepatic tumors.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31431mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31431/samples/