ArrayExpress Uploader0mouse10-week-oldfrataxin KO10-week-oldfrataxin WT10-week-oldfrataxin WT10-week-oldfrataxin KO4-week-oldfrataxin KO4-week-oldfrataxin WT4-week-oldfrataxin KO4-week-oldfrataxin WT6576arrayexpress_sid6Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO)...E-GEOD-31208/profile/8773/arrayexpressuploader28cardiomyopathydegenerative diseasediseasefriedreich's ataxiagenomeheartDec.12, 2014Falseexpression-data-of-mck-conditional-frataxin-knockE-GEOD-31208_A-AFFY-45Expression data of MCK conditional frataxin knock-out miceNov.11, 2014Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO) mice of this mouse model of FA exhibit classical cardiomyopathy of the patients. The onset of FA phenotypes in the KO mice is approximately 6-7 weeks of age. This genearray analysis was conducted to examine the changes in gene expression in the heart of KO mice relative to their wild-type (WT) littermates at 4- and 10-weeks of age. At 10-weeks of age, the KO mice begin to die from severe cardiomyopathy. RNA from the heart of four female 4-week-old MCK littermates (two WT and two KO) and four female 10-week-old MCK littermates (two WT and two KO) was extracted and hybridised to Affymetrix Mouse Genome 430 2.0 Array.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31208http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31208/samples/