{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM773528": {"AGE": "10-week-old", "GENOTYPE": "frataxin KO"}}, {"GSM773529": {"AGE": "10-week-old", "GENOTYPE": "frataxin WT"}}, {"GSM773529": {"AGE": "10-week-old", "GENOTYPE": "frataxin WT"}}, {"GSM773528": {"AGE": "10-week-old", "GENOTYPE": "frataxin KO"}}, {"GSM773532": {"AGE": "4-week-old", "GENOTYPE": "frataxin KO"}}, {"GSM773533": {"AGE": "4-week-old", "GENOTYPE": "frataxin WT"}}, {"GSM773532": {"AGE": "4-week-old", "GENOTYPE": "frataxin KO"}}, {"GSM773533": {"AGE": "4-week-old", "GENOTYPE": "frataxin WT"}}], "id": 6576, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO)...", "geo_gse_id": "E-GEOD-31208", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 8, "tags": ["cardiomyopathy", "degenerative disease", "disease", "friedreich's ataxia", "genome", "heart"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-of-mck-conditional-frataxin-knock", "geo_id_plat": "E-GEOD-31208_A-AFFY-45", "name": "Expression data of MCK conditional frataxin knock-out mice", "created": "Nov.11, 2014", "summary": "Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO) mice of this mouse model of FA exhibit classical cardiomyopathy of the patients. The onset of FA phenotypes in the KO mice is approximately 6-7 weeks of age. This genearray analysis was conducted to examine the changes in gene expression in the heart of KO mice relative to their wild-type (WT) littermates at 4- and 10-weeks of age. At 10-weeks of age, the KO mice begin to die from severe cardiomyopathy. RNA from the heart of four female 4-week-old MCK littermates (two WT and two KO) and four female 10-week-old MCK littermates (two WT and two KO) was extracted and hybridised to Affymetrix Mouse Genome 430 2.0 Array.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31208", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31208/samples/"}