ArrayExpress Uploader0humanbasalfemale104 yearsC139starvationfemale104 yearsC139basalmale100 yearsC402starvationmale100 yearsC402basalmale40 yearsC499starvationmale40 yearsC499basalmale28 yearsC639starvationmale28 yearsC639basalmale106 yearsC645starvationmale106 yearsC645basalfemale37 yearsC931starvationfemale37 yearsC9314185arrayexpress_sid4Human lymphoblastoid cell lines (EBV-immortalised B cells, LcL) obtained from subjects of different age (young 28-40 years, centenarians...E-GEOD-31040/profile/8773/arrayexpressuploader412basalcellcompartmentserumDec.12, 2014Falsegene-expression-analysis-of-human-lymphoblastoid-cE-GEOD-31040_A-AFFY-44Gene expression analysis of human lymphoblastoid cell linesSep.16, 2014Human lymphoblastoid cell lines (EBV-immortalised B cells, LcL) obtained from subjects of different age (young 28-40 years, centenarians >95 years) were analysed for gene expression at basal culture conditions and after 48 hours of serum starvation. Lymphoid B cells from centenarians were more resistant to apoptosis induction and displayed a more developed lysosomal compartment, the most critical component of phagic machinery. In addition, cells from centenarians were capable of engulfing and digesting other cells, i.e. their siblings (even entire cells). This behavior was improved by nutrient deprivation but, strikingly, it was unaffected by the autophagy modulating drugs rapamycin, an autophagy inducer, and 3-methyladenine, an autophagy inhibitor. 12 samples, divided into 4 groups: young basal, young starved, centenarians basal and centenarians starved.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31040http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31040/samples/