Dataset: Profiling of Jurkat T cells activated with CD3, CD28 and PMA and multiple kinase inhibitors
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype,...
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype, depending on environmental co-stimulatory signals. In order to identify the genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed comprehensive transcriptome analyses of Jurkat T cells stimulated with various stimuli an pathway inhibitors Jurkat T cells were treated with CD3, CD28 and PMA and all pairwise combinations, in the presence of DMSO (control) or kinase inhibitors. RNA was isolated after 8 hrs incubation.
- Species:
- human
- Samples:
- 56
- Source:
- E-GEOD-30674
- Updated:
- Dec.12, 2014
- Registered:
- Sep.16, 2014
Factors:
(via ArrayExpress)
| Sample | TREATMENT |
|---|---|
| GSM760712 | control |
| GSM760712 | control |
| GSM760712 | control |
| GSM760715 | CD28 |
| GSM760715 | CD28 |
| GSM760717 | CD3 |
| GSM760717 | CD3 |
| GSM760717 | CD3 |
| GSM760720 | PMA |
| GSM760720 | PMA |
| GSM760720 | PMA |
| GSM760723 | CD28, PMA, Control |
| GSM760723 | CD28, PMA, Control |
| GSM760723 | CD28, PMA, Control |
| GSM760726 | CD28, CD3, Control |
| GSM760726 | CD28, CD3, Control |
| GSM760726 | CD28, CD3, Control |
| GSM760729 | PMA, CD3, Control |
| GSM760729 | PMA, CD3, Control |
| GSM760729 | PMA, CD3, Control |
| GSM760732 | CD28, PMA, A_420983 |
| GSM760732 | CD28, PMA, A_420983 |
| GSM760734 | CD28, PMA, CsA |
| GSM760734 | CD28, PMA, CsA |
| GSM760736 | CD28, PMA, AEB, 071 |
| GSM760736 | CD28, PMA, AEB, 071 |
| GSM760738 | CD28, PMA, Org48762 |
| GSM760738 | CD28, PMA, Org48762 |
| GSM760740 | CD28, PMA, SP600125 |
| GSM760740 | CD28, PMA, SP600125 |
| GSM760742 | CD28, PMA, PD98059 |
| GSM760742 | CD28, PMA, PD98059 |
| GSM760744 | CD28, CD3, A_420983 |
| GSM760744 | CD28, CD3, A_420983 |
| GSM760746 | CD28, CD3, CsA |
| GSM760746 | CD28, CD3, CsA |
| GSM760748 | CD28, CD3, AEB, 071 |
| GSM760748 | CD28, CD3, AEB, 071 |
| GSM760750 | CD28, CD3, Org48762 |
| GSM760750 | CD28, CD3, Org48762 |
| GSM760752 | CD28, CD3, SP600125 |
| GSM760752 | CD28, CD3, SP600125 |
| GSM760754 | CD28, CD3, PD98059 |
| GSM760754 | CD28, CD3, PD98059 |
| GSM760756 | PMA, CD3, A_420983 |
| GSM760756 | PMA, CD3, A_420983 |
| GSM760758 | PMA, CD3, CsA |
| GSM760758 | PMA, CD3, CsA |
| GSM760760 | PMA, CD3, AEB, 071 |
| GSM760760 | PMA, CD3, AEB, 071 |
| GSM760762 | PMA, CD3, Org48762 |
| GSM760762 | PMA, CD3, Org48762 |
| GSM760764 | PMA, CD3, SP600125 |
| GSM760764 | PMA, CD3, SP600125 |
| GSM760766 | PMA, CD3, PD98059 |
| GSM760766 | PMA, CD3, PD98059 |