{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM759894 1": {}}, {"GSM759895 1": {}}, {"GSM759896 1": {}}, {"GSM759897 1": {}}, {"GSM759898 1": {}}, {"GSM759899 1": {}}, {"GSM759900 1": {}}, {"GSM759901 1": {}}, {"GSM759902 1": {}}, {"GSM759903 1": {}}, {"GSM759904 1": {}}, {"GSM759905 1": {}}, {"GSM759906 1": {}}, {"GSM759907 1": {}}], "id": 4172, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "We have used an agnostic approach to identify drug combinations by using combination high throughput screening (cHTS) technology and make...", "geo_gse_id": "E-GEOD-30644", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 14, "tags": ["cell", "line", "multiple myeloma", "myeloma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "microarray-analysis-of-a-multiple-myeloma-cell-lin", "geo_id_plat": "E-GEOD-30644_A-AFFY-44", "name": "Microarray analysis of a multiple myeloma cell line, MM1S, treated with adenosine A2A and Beta-2 Adrenergic Receptor agonists in combination with dexamethasone", "created": "Sep.16, 2014", "summary": "We have used an agnostic approach to identify drug combinations by using combination high throughput screening (cHTS) technology and make the surprising discovery that adenosine A2A and beta-2 adrenergic receptor agonists are highly synergistic, selective and novel agents that enhance glucocorticoid activity in B-cell malignancies. We used the microarray study to understand the synergistic mechanism between dexamethasone and A2A receptor agonist or Beta-2 Adrenergic receptor agonist in a multiple myeloma cell line, MM1S. MM1S cells were treated with CGS-21680 or Salmeterol alone, or in combination with dexamethasone for six hours for RNA extraction and hybridization on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30644", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30644/samples/"}