{"platform": 6, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM753450": {"TREATMENT": "endothelin-1", "GENOTYPE": "FAK -/-"}}, {"GSM75345": {"TREATMENT": "endothelin-1", "GENOTYPE": "FAK +/+"}}, {"GSM753452": {"TREATMENT": "untreated", "GENOTYPE": "FAK -/-"}}, {"GSM753453": {"TREATMENT": "untreated", "GENOTYPE": "FAK +/+"}}], "id": 6516, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30356", "summary_wrapped": "Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We...", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 4, "tags": ["genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-fak-null-mouse-embryonic-fibr", "geo_id_plat": "E-GEOD-30356_A-AFFY-45", "name": "Expression data from FAK null mouse embryonic fibroblasts treated with endothelin-1", "created": "Nov.11, 2014", "summary": "Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We investigated the molecular pathways in the transmission of ET-1 signals that lead to features of connective tissue remodeling, in particular the role of FAK (focal adhesion kinase). We used microarrays to investigated whether FAK is required for ET-1 to promote the global programme of gene expression underlying myofibroblast formation and identified distinct classes of up-regulated genes during this process. Genes whose induction by ET-1 required FAK Affymetrix Mouse Genome 430 2.0 GeneChips were used to identify differential gene expression changes bewteen samples.", "geo_gse_id": "E-GEOD-30356", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30356/samples/"}