ArrayExpress Uploader0human cell lineastrocyte cell lineastrocyte cell lineastrocyte cell lineastrocyte cell lineastrocyte cell lineastrocyte4150arrayexpress_sid4Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is...E-GEOD-30336/profile/8773/arrayexpressuploader36cellgliomalineDec.12, 2014Falseexpression-analysis-of-52-glioma-clinical-samplesE-GEOD-30336_A-AFFY-44Expression analysis of 52 glioma clinical samples (36 CIMP+ and 16 CIMP-) and 6 cell line samplesSep.16, 2014Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome. In this study 52 glioma clinic samples (36 CIMP+ and 16 CIMP-) were analyzed. Parental IDH1 wild-type and IDH1 mutant cells were passaged 40 and passage 40 were cell line was sent for expression array.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30336http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30336/samples/