{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM748815": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "0h"}}, {"GSM748815": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "0h"}}, {"GSM748815": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "0h"}}, {"GSM748818": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "3h"}}, {"GSM748818": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "3h"}}, {"GSM748818": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "3h"}}, {"GSM74882": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "6h"}}, {"GSM74882": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "6h"}}, {"GSM74882": {"STRESS": "untreated", "CELL LINE": "G361", "TIME": "6h"}}, {"GSM748824": {"STRESS": "5 Gy IR", "CELL LINE": "G361", "TIME": "3h"}}, {"GSM748824": {"STRESS": "5 Gy IR", "CELL LINE": "G361", "TIME": "3h"}}, {"GSM748824": {"STRESS": "5 Gy IR", "CELL LINE": "G361", "TIME": "3h"}}, 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{"STRESS": "untreated", "CELL LINE": "U2OS", "TIME": "6h"}}, {"GSM748866": {"STRESS": "untreated", "CELL LINE": "U2OS", "TIME": "6h"}}, {"GSM748869": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "3h"}}, {"GSM748869": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "3h"}}, {"GSM748869": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "3h"}}, {"GSM748872": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "6h"}}, {"GSM748872": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "6h"}}, {"GSM748872": {"STRESS": "5 Gy IR", "CELL LINE": "U2OS", "TIME": "6h"}}, {"GSM74987": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "0h"}}, {"GSM74987": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "0h"}}, {"GSM74987": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "0h"}}, {"GSM749874": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749874": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749874": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749877": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "6h"}}, {"GSM749877": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "6h"}}, {"GSM749877": {"STRESS": "untreated", "CELL LINE": "BJ", "TIME": "6h"}}, {"GSM749880": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749880": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749880": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "3h"}}, {"GSM749883": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "6h"}}, {"GSM749883": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "6h"}}, {"GSM749883": {"STRESS": "5 Gy IR", "CELL LINE": "BJ", "TIME": "6h"}}], "id": 4146, "pop_total": 0, "platform": 4, "summary_wrapped": "The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The...", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 75, "tags": ["cancer", "cell", "line"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-30240_A-AFFY-44", "slug": "expression-data-from-5-human-cell-lines-exposed-to", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30240", "geo_gds_id": "", "name": "Expression data from 5 human cell lines exposed to IR (5 Gy)", "created": "Sep.16, 2014", "summary": "The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed transcriptional responses to ionizing radiation (IR) in 5 human cell lines to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles most of the responses were cell line-specific. Data analysis identified significant enrichment for p53 target genes and cell cycle-related pathways among groups of up-regulated and down-regulated genes, respectively. Expression profiles were measured using affymetrix chips in IR- irradiated G361 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy  Expression profiles were measured using affymetrix chips in IR- irradiated HepG2 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy  Expression profiles were measured using affymetrix chips in IR- irradiated TK6 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy  Expression profiles were measured using affymetrix chips in IR- irradiated U2OS cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy  Expression profiles were measured using affymetrix chips in IR- irradiated BJ cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy", "geo_gse_id": "E-GEOD-30240", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30240/samples/"}