ArrayExpress Uploaderarrayexpress_sidhumanuntreatedG3610huntreatedG3610huntreatedG3610huntreatedG3613huntreatedG3613huntreatedG3613huntreatedG3616huntreatedG3616huntreatedG3616h5 Gy IRG3613h5 Gy IRG3613h5 Gy IRG3613h5 Gy IRG3616h5 Gy IRG3616h5 Gy IRG3616huntreatedHepG20huntreatedHepG20huntreatedHepG20huntreatedHepG23huntreatedHepG23huntreatedHepG23huntreatedHepG26huntreatedHepG26huntreatedHepG26h5 Gy IRHepG23h5 Gy IRHepG23h5 Gy IRHepG23h5 Gy IRHepG26h5 Gy IRHepG26h5 Gy IRHepG26huntreatedTK60huntreatedTK60huntreatedTK60huntreatedTK63huntreatedTK63huntreatedTK63huntreatedTK66huntreatedTK66huntreatedTK66h5 Gy IRTK63h5 Gy IRTK63h5 Gy IRTK63h5 Gy IRTK66h5 Gy IRTK66h5 Gy IRTK66huntreatedU2OS0huntreatedU2OS0huntreatedU2OS0huntreatedU2OS3huntreatedU2OS3huntreatedU2OS3huntreatedU2OS6huntreatedU2OS6huntreatedU2OS6h5 Gy IRU2OS3h5 Gy IRU2OS3h5 Gy IRU2OS3h5 Gy IRU2OS6h5 Gy IRU2OS6h5 Gy IRU2OS6huntreatedBJ0huntreatedBJ0huntreatedBJ0huntreatedBJ3huntreatedBJ3huntreatedBJ3huntreatedBJ6huntreatedBJ6huntreatedBJ6h5 Gy IRBJ3h5 Gy IRBJ3h5 Gy IRBJ3h5 Gy IRBJ6h5 Gy IRBJ6h5 Gy IRBJ6h414604The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The.../profile/8773/arrayexpressuploader375cancercelllineDec.12, 2014FalseE-GEOD-30240_A-AFFY-44expression-data-from-5-human-cell-lines-exposed-tohttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30240Expression data from 5 human cell lines exposed to IR (5 Gy)Sep.16, 2014The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed transcriptional responses to ionizing radiation (IR) in 5 human cell lines to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles most of the responses were cell line-specific. Data analysis identified significant enrichment for p53 target genes and cell cycle-related pathways among groups of up-regulated and down-regulated genes, respectively. Expression profiles were measured using affymetrix chips in IR- irradiated G361 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy Expression profiles were measured using affymetrix chips in IR- irradiated HepG2 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy Expression profiles were measured using affymetrix chips in IR- irradiated TK6 cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy Expression profiles were measured using affymetrix chips in IR- irradiated U2OS cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 Gy Expression profiles were measured using affymetrix chips in IR- irradiated BJ cells and their time-matched untreated controls. Time points recorded were 0, 3 and 6 hrs. IR dose: 5 GyE-GEOD-30240http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30240/samples/