{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM747424": {"UPN": "127804", "IPSS": "0.5", "PLATELET (X10^3/MCL)": "195", "GENOTYPE": "no U2AF1 mutation", "AGE ON STUDY": "64", "WBC (X10^3/MCL)": "2.3", "BANKING DATE": "8/3/2005", "CYTOGENETICS": "46, XY[20]", "BONE MARROW MYELOBLAST(%)": "2", "CYTOGENETIC RISK GROUP": "Good", "SEX": "male", "DISEASE STATE": "myelodysplastic syndrome", "RACE": "White", "ANC (X10^3/MCL)": "1.4", "HEMOGLOBIN (G/DL)": "8.9", "FAB": "RA", "DURATION OF DISEASE (MONTH)": "0", "CELL TYPE": "CD34+ purified MDS bone marrow", "DIAGNOSIS DATE": "2005-08-03"}}, {"GSM747425": {"UPN": "300813", "IPSS": "0", "PLATELET (X10^3/MCL)": "243", "GENOTYPE": "U2AF1 mutation", "AGE ON STUDY": "41", "WBC (X10^3/MCL)": "2.7", "BANKING DATE": "7/12/2005", "CYTOGENETICS": "46, XX[20]", "BONE MARROW MYELOBLAST(%)": "2", "CYTOGENETIC RISK GROUP": "Good", "SEX": "female", "DISEASE STATE": "myelodysplastic syndrome", "RACE": "White", "ANC 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"female", "DISEASE STATE": "myelodysplastic syndrome", "RACE": "White", "ANC (X10^3/MCL)": "2.3", "HEMOGLOBIN (G/DL)": "8.8", "FAB": "RAEB", "DURATION OF DISEASE (MONTH)": "0", "CELL TYPE": "CD34+ purified MDS bone marrow", "DIAGNOSIS DATE": "2006-05-01"}}, {"GSM747433": {"UPN": "703653", "IPSS": "0.5", "PLATELET (X10^3/MCL)": "27", "GENOTYPE": "no U2AF1 mutation", "AGE ON STUDY": "20", "WBC (X10^3/MCL)": "3", "BANKING DATE": "2/2/2005", "CYTOGENETICS": "46,XX[20]", "BONE MARROW MYELOBLAST(%)": "0", "CYTOGENETIC RISK GROUP": "Good", "SEX": "female", "DISEASE STATE": "myelodysplastic syndrome", "RACE": "White", "ANC (X10^3/MCL)": "0.6", "HEMOGLOBIN (G/DL)": "8.4", "FAB": "RA", "DURATION OF DISEASE (MONTH)": "0", "CELL TYPE": "CD34+ purified MDS bone marrow", "DIAGNOSIS DATE": "2005-02-02"}}, {"GSM747434": {"UPN": "705782", "IPSS": "1", "PLATELET (X10^3/MCL)": "28", "GENOTYPE": "no U2AF1 mutation", "AGE ON STUDY": "34", "WBC (X10^3/MCL)": "3.3", "BANKING DATE": "8/4/2006", 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DATE": "unknown", "CYTOGENETICS": "unknown", "BONE MARROW MYELOBLAST(%)": "unknown", "CYTOGENETIC RISK GROUP": "unknown", "SEX": "unknown", "DISEASE STATE": "control", "RACE": "unknown", "ANC (X10^3/MCL)": "unknown", "HEMOGLOBIN (G/DL)": "unknown", "FAB": "unknown", "DURATION OF DISEASE (MONTH)": "unknown", "CELL TYPE": "CD34+ purified control bone marrow", "DIAGNOSIS DATE": "unknown"}}, {"GSM747439": {"UPN": "not specified", "IPSS": "unknown", "PLATELET (X10^3/MCL)": "unknown", "GENOTYPE": "control", "AGE ON STUDY": "unknown", "WBC (X10^3/MCL)": "unknown", "BANKING DATE": "unknown", "CYTOGENETICS": "unknown", "BONE MARROW MYELOBLAST(%)": "unknown", "CYTOGENETIC RISK GROUP": "unknown", "SEX": "unknown", "DISEASE STATE": "control", "RACE": "unknown", "ANC (X10^3/MCL)": "unknown", "HEMOGLOBIN (G/DL)": "unknown", "FAB": "unknown", "DURATION OF DISEASE (MONTH)": "unknown", "CELL TYPE": "CD34+ purified control bone marrow", "DIAGNOSIS DATE": "unknown"}}], "id": 4143, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Myelodysplastic syndromes (MDS) are a heterogenous group of hematopoietic stem cell disorders characterized by dysplastic blood cell...", "geo_gse_id": "E-GEOD-30195", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 19, "sample_count": 19, "tags": ["acute myeloid leukemia", "blood cell", "bone", "bone marrow", "cell", "leukemia", "myeloid leukemia", "peripheral", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiling-in-myelodysplastic-syndr", "geo_id_plat": "E-GEOD-30195_A-AFFY-44", "name": "Gene expression profiling in myelodysplastic syndromes", "created": "Sep.16, 2014", "summary": "Myelodysplastic syndromes (MDS) are a heterogenous group of hematopoietic stem cell disorders characterized by dysplastic blood cell formation and peripheral blood cytopenias.  Up to 30% of patients with MDS will progress to a highly chemotherapy-resistant secondary acute myeloid leukemia (sAML).  We identified mutations in U2AF1 in MDS patients and patients with U2AF1 mutations are at an increased risk of developing sAML. We identified mutations in U2AF1 in patients with MDS and hypothesized that U2AF1 mutations may represent a novel mechanism that could alter gene expression in MDS. To elucidate gene expression changes associated with U2AF1  mutations, we analyzed the global mRNA expression profile obtained from bone marrow CD34+ cells purified from 5 MDS patients with a U2AF1 mutation, 10 MDS patients without a mutation, and 4 normal donors.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30195", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30195/samples/"}