ArrayExpress Uploader0human5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazole5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazole5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazoleLatrunculin BLatrunculin BN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amideN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amideN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amide5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazole5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazole5,​6-​dichloro-​1-​β-​D-​ribofuranosyl-​1H-​benzimidazoleLatrunculin BLatrunculin BLatrunculin BN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amideN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amideN-[2-(4-chloroanilino)-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl) benz�amideDMSO controlDMSO controlDMSO control2453arrayexpress_sid4Analysis of serum starved PC-3 cells treated with CCG-1423, Latrunculin B, or the transcription elongation inhibitor DRB for 2 or 24...E-GEOD-30188/profile/8773/arrayexpressuploader120actincancerserumDec.12, 2014Falserho-transcription-inhibitor-ccg-1423-effect-on-pcE-GEOD-30188_A-AFFY-44Rho transcription inhibitor CCG-1423 effect on PC-3 cellsJul.12, 2014Analysis of serum starved PC-3 cells treated with CCG-1423, Latrunculin B, or the transcription elongation inhibitor DRB for 2 or 24 hours. Results provide insights to potential therapeutic approaches to cancer metastasis. Twenty one samples in triplicate were analyzed and compared to the DMSO-treated control. The primary condition tested was the effect of the Rho-transcription pathway inhibitor, CCG-1423 As a biologically related control, the actin polymerization inhibitor, Latrunculin B, that also blocks Rho-stimulated gene transcription was tested. As a control for non-specific transcription inhibition, DRB was used. All samples, 2-hr and 24-hr treated samples were compared to the 24-hr DMSO sample.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30188http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30188/samples/