ArrayExpress Uploader0humanSystemic lupus erythematosous (SLE)patient1Systemic lupus erythematosous (SLE)patient2Systemic lupus erythematosous (SLE)patient3Systemic lupus erythematosous (SLE)patient4Systemic lupus erythematosous (SLE)patient5Systemic lupus erythematosous (SLE)patient6Systemic lupus erythematosous (SLE)patient7Systemic lupus erythematosous (SLE)patient8Systemic lupus erythematosous (SLE)patient9Systemic lupus erythematosous (SLE)patient10Systemic lupus erythematosous (SLE)patient11Systemic lupus erythematosous (SLE)patient12Systemic lupus erythematosous (SLE)patient13Systemic lupus erythematosous (SLE)patient14Systemic lupus erythematosous (SLE)patient15Systemic lupus erythematosous (SLE)patient16Systemic lupus erythematosous (SLE)patient17controlControl1controlControl2controlControl3controlControl4controlControl5controlControl6controlControl8controlControl9controlControl104141arrayexpress_sid4Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes...E-GEOD-30153/profile/8773/arrayexpressuploader226autoimmune diseasecellcentraldiseasehypergammaglobulinemialupusperipheralDec.12, 2014FalseE-GEOD-30153_A-AFFY-44b-cell-signature-during-inactive-systemic-lupusB cell signature during inactive systemic lupusSep.16, 2014Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes. 17 patients with quiescent lupus (patient1-17) versus 9 controls (Control1-6,Control8-10).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30153http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30153/samples/