ArrayExpress Uploader04136not specifiednot specifiedDMSOALLSILnot specifiednot specifiedCmpdEALLSILICNDMSOnot specifiedALLSILICNCmpdEnot specifiedALLSILcMycDMSOnot specifiedALLSILcMycCmpdEnot specifiedALLSILnot specifiednot specifiedDMSODND41not specifiednot specifiedCmpdEDND41ICNDMSOnot specifiedDND41ICNCmpdEnot specifiedDND41cMycDMSOnot specifiedDND41cMycCmpdEnot specifiedDND41not specifiednot specifiedDMSOHPBALLnot specifiednot specifiedCmpdEHPBALLICNDMSOnot specifiedHPBALLICNCmpdEnot specifiedHPBALLcMycDMSOnot specifiedHPBALLcMycCmpdEnot specifiedHPBALLnot specifiednot specifiedDMSOKOPTK1not specifiednot specifiedCmpdEKOPTK1ICNDMSOnot specifiedKOPTK1ICNCmpdEnot specifiedKOPTK1cMycDMSOnot specifiedKOPTK1cMycCmpdEnot specifiedKOPTK1not specifiednot specifiedDMSOTALL-1not specifiednot specifiedCmpdETALL-1ICNDMSOnot specifiedTALL-1ICNCmpdEnot specifiedTALL-1cMycDMSOnot specifiedTALL-1cMycCmpdEnot specifiedTALL-1arrayexpress_sid4Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase...21807868/profile/8773/arrayexpressuploader430celllinenotchDec.12, 2014FalseE-GEOD-29959_A-AFFY-44human-t-all-cell-line-response-to-inhibition-of-nohttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29959Human T-ALL cell line response to inhibition of Notch signalingSep.16, 2014Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase inhibitor (GSI) to block Notch signaling. Samples include parental cells, cells rescued by retroviral transduction with ICN (a GSI-independent form of activated Notch1), and cells retrovirally transduced with c-Myc (an important downstream target of Notch1). Results allow segregation of bona fide Notch targets from other genes affected by gamma-secretase inhibition as well as from targets downstream of c-Myc. Thirty samples were analyzed. Five human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) were treated with gamma-secretase inhibitor (1.0 micromolar compound E) vs. DMSO vehicle control for 12 hours. Each cell line was also retrovirally transduced with ICN or c-Myc, FACS sorted, and then treated with GSI vs. DMSO.E-GEOD-29959humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29959/samples/