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Home › Dataset Library › Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy (ARVC)

Dataset: Myocardial transcriptome analysis of human arrhythmogenic right ventricular cardiomyopathy (ARVC)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy primarily of the right ventricle characterized...

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy primarily of the right ventricle characterized through fibrofatty replacement of cardiomyocytes. The genetic etiology in ARVC patients is most commonly caused by dominant inheritance and high genetic heterogeneity. Though histological examinations of ARVC affected human myocardium reveals fibrolipomatous replacement, the molecular mechanisms leading to loss of cardiomyocytes are largely unknown. We therefore analyzed the transcriptomes of 6 ARVC specimen derived from heart transplantation candidates and compared our findings to 6 non-failing donor hearts (NF) which could not be transplanted for technical reasons. In addition, we compared our findings to 7 hearts from patients with idiopathic dilated cardiomyopathy. From each heart left (LV) and right ventricular (RV) myocardial samples were analyzed by Affymetrix HG-U133 Plus 2.0 arrays, adding up to six sample groups. Unsupervised cluster analyses of the six sample groups revealed a clear separation of NF and cardiomyopathy samples. However, in contrast to the other samples, unsupervised cluster analyses revealed no distinct expression pattern in LV and RV samples from ARVC-hearts. We further identified differentially expressed transcripts using t-tests and found transcripts separating diseased and NF ventricular myocardium. Of note, in failing myocardium only about 15-16% of the genes are commonly regulated compared to NF samples. In addition both cardiomyopathies are clearly distinct on the transcriptome level. Comparison of the expression patterns between the failing RV and LV using a paired t-test revealed a lack of major differences between LV and RV gene expression in ARVC hearts. Microarrays were used to elucidate the differences between non-failing control hearts and those, suffering from arrhythmogenic right ventricular cardiomyopathy (ARVC).

Species:
human

Samples:
38

Source:
E-GEOD-29819

Updated:
Dec.12, 2014

Registered:
Sep.16, 2014


Factors: (via ArrayExpress)
Sample VENTRICLE AGE INDICATION GENDER
GSM738990 left 53 arrhythmogenic right ventricular cardiomyopathy w
GSM73899 right 53 arrhythmogenic right ventricular cardiomyopathy w
GSM738992 left 47 arrhythmogenic right ventricular cardiomyopathy m
GSM738993 right 47 arrhythmogenic right ventricular cardiomyopathy m
GSM738994 left 30 arrhythmogenic right ventricular cardiomyopathy m
GSM738995 right 30 arrhythmogenic right ventricular cardiomyopathy m
GSM738996 left 43 arrhythmogenic right ventricular cardiomyopathy m
GSM738997 right 43 arrhythmogenic right ventricular cardiomyopathy m
GSM738998 left 15 arrhythmogenic right ventricular cardiomyopathy w
GSM738999 right 15 arrhythmogenic right ventricular cardiomyopathy w
GSM739000 left 18 arrhythmogenic right ventricular cardiomyopathy m
GSM73900 right 18 arrhythmogenic right ventricular cardiomyopathy m
GSM739002 left 46 Dilated cardiomyopathy f
GSM739003 right 46 Dilated cardiomyopathy f
GSM739004 left 57 Dilated cardiomyopathy f
GSM739005 right 57 Dilated cardiomyopathy f
GSM739006 left 61 Dilated cardiomyopathy f
GSM739007 right 61 Dilated cardiomyopathy f
GSM739004 left 57 Dilated cardiomyopathy f
GSM739005 right 57 Dilated cardiomyopathy f
GSM739010 left 66 Dilated cardiomyopathy m
GSM7390 right 66 Dilated cardiomyopathy m
GSM739012 left 59 Dilated cardiomyopathy m
GSM739013 right 59 Dilated cardiomyopathy m
GSM739014 left 57 Dilated cardiomyopathy m
GSM739015 right 57 Dilated cardiomyopathy m
GSM739016 left 28 Non-Failing m
GSM739017 right 28 Non-Failing m
GSM739018 left 23 Non-Failing f
GSM739019 right 23 Non-Failing f
GSM739020 left 61 Non-Failing m
GSM73902 right 61 Non-Failing m
GSM739022 left 50 Non-Failing m
GSM739023 right 50 Non-Failing m
GSM739024 left n.a. Non-Failing n.a.
GSM739025 right n.a. Non-Failing n.a.
GSM739026 left 64 Non-Failing f
GSM739027 right 64 Non-Failing f

Tags

  • arrhythmogenic right ventricular cardiomyopathy
  • cardiomyopathy
  • dilated cardiomyopathy
  • heart
  • left
  • myocardium
  • right
  • right ventricle
  • ventricle

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