Dataset: Gene expression data from chronic lymphocytic leukemia samples
MicroRNA-155 is frequently over-expressed in CLL and is associated with worse clinical prognosis. To understand the role of miR-155 in...
MicroRNA-155 is frequently over-expressed in CLL and is associated with worse clinical prognosis. To understand the role of miR-155 in CLL pathogenesis, we used microarrays to identify genes that are expressed at significantly lower levels in CLLs that harbor higher levels of miR-155 expression in an attempt to determine the relevant gene targets of miR-155 in CLL. MiR-155 levels of 38 CLL samples were determined and ranked. 6 CLLs with the highest and 6 CLLs with the lowest miR-155 within the IgVH unmutated group, and 5 CLLs with the highest and 5 CLLs with the lowest miR-155 within the IgVH mutated group were selected for Affymetrix array analyses.
- Species:
- human
- Samples:
- 22
- Source:
- E-GEOD-29605
- Updated:
- Dec.12, 2014
- Registered:
- Sep.16, 2014
| Sample | EXPRESSION | CELL TYPE | MUTATION |
|---|---|---|---|
| GSM733547 | high miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733548 | high miR-155 | purified CLL B cells, lymph node | unmutated IgVH |
| GSM733547 | high miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733547 | high miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733547 | high miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733547 | high miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733553 | low miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733554 | low miR-155 | purified CLL B cells, spleen | unmutated IgVH |
| GSM733553 | low miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733553 | low miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733553 | low miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733553 | low miR-155 | purified CLL B cells, peripheral blood | unmutated IgVH |
| GSM733559 | high miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733559 | high miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733559 | high miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733559 | high miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733559 | high miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733564 | low miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733564 | low miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733564 | low miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733564 | low miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |
| GSM733564 | low miR-155 | purified CLL B cells, peripheral blood | mutated IgVH |