ArrayExpress Uploaderarrayexpress_sidmouseAin76A3 monthswild typecryptAin76A3 monthswild typecryptAin76A3 monthswild typecryptAin76A3 monthswild typecryptAin76A3 monthsApc1638N/+cryptAin76A3 monthsApc1638N/+cryptAin76A3 monthsApc1638N/+cryptAin76A3 monthsApc1638N/+cryptAin76A3 monthsp21-/-cryptAin76A3 monthsp21-/-cryptAin76A3 monthsp21-/-cryptAin76A3 monthsp21-/-cryptAin76A3 monthswild typevillusAin76A3 monthswild typevillusAin76A3 monthswild typevillusAin76A3 monthswild typevillusAin76A3 monthsApc1638N/+villusAin76A3 monthsApc1638N/+villusAin76A3 monthsApc1638N/+villusAin76A3 monthsApc1638N/+villusAin76A3 monthsp21-/-villusAin76A3 monthsp21-/-villusAin76A3 monthsp21-/-villusAin76A3 monthsp21-/-villusAin76A1 yearwild typecryptAin76A1 yearwild typecryptAin76A1 yearwild typecryptAin76A1 yearwild typecryptNWD11 yearwild typecryptNWD11 yearwild typecryptNWD11 yearwild typecryptNWD11 yearwild typecryptNWD21 yearwild typecryptNWD21 yearwild typecryptNWD21 yearwild typecryptNWD21 yearwild typecryptAin76A1 yearwild typevillusAin76A1 yearwild typevillusAin76A1 yearwild typevillusAin76A1 yearwild typevillusNWD11 yearwild typevillusNWD11 yearwild typevillusNWD11 yearwild typevillusNWD11 yearwild typevillusNWD21 yearwild typevillusNWD21 yearwild typevillusNWD21 yearwild typevillus648206Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotypes, demonstrating that diet and genetic...21652773E-GEOD-29538/profile/8773/arrayexpressuploader447intestinal tumorsintestinesmall intestineDec.12, 2014Falseexpression-data-of-small-intestine-crypts-and-villE-GEOD-29538_A-AFFY-45Expression data of small intestine crypts and villi from mice with nutritional and genetic risk factors for intestinal tumorsNov.11, 2014Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotypes, demonstrating that diet and genetic factors impact risk by distinct combinatorial mechanisms. We analyzed expression profiles of small intestine crypts and villi from mice with nutritional and genetic risk factors. The results advanced our understanding of the mechanistic roles played by major risk factors in the pathogenesis of intestinal tumors. Small intestine crypts and villi from mice with nutritional (Ain76A, NWD1, and NWD2) and genetic risk factors (WT, Apc1638N/+ and p21-/-) were collected for RNA extraction and analysis using the Affymetrix 3' IVT expression microarray. Three or four replicates per tissue/risk factor.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29538http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-29538/samples/