{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709379": {"ORGANISM PART": "Peritoneal cavity"}}, {"GSM709397": {"ORGANISM PART": "bone marrow"}}, {"GSM709397": {"ORGANISM PART": "bone marrow"}}, {"GSM709397": {"ORGANISM PART": "bone marrow"}}], "id": 6445, "pop_total": 0, "platform": 6, "summary_wrapped": "We have performed a comprehensive transcriptional analysis of specific monocyte and macrophage (M\u00d8) subsets during an acute self-...", "pubmed_id": 24762537, "geo_gse_id": "E-GEOD-28621", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 21, "tags": ["bone", "bone marrow", "cell", "macrophage", "monocyte", "peritoneal cavity"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcriptional-profiles-of-macrophages-in-resolvi", "geo_id_plat": "E-GEOD-28621_A-AFFY-45", "name": "Transcriptional profiles of macrophages in resolving inflammation", "created": "Nov.11, 2014", "summary": "We have performed a comprehensive transcriptional analysis of specific monocyte and macrophage (M\u00d8) subsets during an acute self-resolving inflammatory insult. Following initial induction of acute inflammation, tissue resident (Resident) M\u00d8 are rapidly \u2018cleared\u2019 from the inflammatory foci, only becoming recoverable as inflammation resolves. Monocytes are recruited to the inflammatory lesion where they differentiate into M\u00d8. We term these monocyte-derived M\u00d8 \u2018inflammation-associated\u2019 to distinguish them from Resident M\u00d8 which are present throughout the inflammatory response and can renew during the resolution of inflammation by proliferation. Comparative analysis of the Mo and M\u00d8 populations (both \u2018inflammation-associated\u2019 and Resident M\u00d8) identifies select genes expressed in subsets of \u2018inflammation-associated\u2019 and Resident M\u00d8 that play important roles in the resolution of inflammation and/or for immunity, including molecules involved in antigen presentation, cell cycle and others associated with \u2018immaturity\u2019 and M\u00d8 activation. We purified monocyte and macrophage populations from the peritoneal cavity of C57BL/6 mice 4, 18, 72 and 168 hours after the induction of inflammation with intraperitoneal administration of zymosan (2x10^7 particles). We also purified tissue resident macrophages and Ly-6B+ bone marrow monocytes from naive mice as reference populations.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28621", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28621/samples/"}