ArrayExpress Uploader0human4044arrayexpress_sid4SIRT6 has been implicated in a range of biological processes including inflammation, aging and the control of metabolism. Hence...E-GEOD-28548/profile/8773/arrayexpressuploader024genomeDec.12, 2014Falsethe-effect-of-sirtuin-6-overexpression-on-tnfa-stiE-GEOD-28548_A-AFFY-44The effect of sirtuin 6 overexpression on TNFa stimulation.Sep.16, 2014SIRT6 has been implicated in a range of biological processes including inflammation, aging and the control of metabolism. Hence inhibitors or activators of SIRT6 have the potential to be therapeutics for a number of indications. Genome wide expression studies were used to investigate the effect of overexpression of SIRT6 and mutant SIRT6 on a wide range of NFκB dependent gene expression HEK293 cells were transfected with expression vectors encoding wild type SIRT6 or the H133W mutant followed by stimulation with TNFα for one hour.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28548http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28548/samples/