{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 4023, "factors": [{"GSM700742": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "wt", "CELL LINE": "M980513", "TUMOR STAGE": "T2aN3M1c", "CELL ORIGIN": "Lymph node metastasis iliacal", "BRAF": "V600E"}}, {"GSM700743": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "Q61R", "CELL LINE": "M010817", "TUMOR STAGE": "TxN1bM1c", "CELL ORIGIN": "Skin metastasis left upper arm", "BRAF": "wt"}}, {"GSM700744": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "Q61L", "CELL LINE": "M050829", "TUMOR STAGE": "T3aN3M0", "CELL ORIGIN": "Skin metastasis retrauricular right", "BRAF": "wt"}}, {"GSM700745": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "wt", "CELL LINE": "M000921", "TUMOR STAGE": "TxNxM1c", "CELL ORIGIN": "Epigastric metastasis", "BRAF": "V600E"}}, {"GSM700746": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "G12D", "CELL LINE": "M080423", "TUMOR STAGE": "T3bN1aM1a", "CELL ORIGIN": "Lymph node metastasis hepatoduodenal", "BRAF": "wt"}}, {"GSM700747": {"CELL CULTURE PHENOTYPE": "proliferative", "NRAS": "wt", "CELL LINE": "M080326", "TUMOR STAGE": "T4bN2aM0", "CELL ORIGIN": "Primary plantar", "BRAF": "V600E"}}, {"GSM700748": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M080306", "TUMOR STAGE": "T2N1bM0", "CELL ORIGIN": "Primary capillitium", "BRAF": "wt"}}, {"GSM700749": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M061103", "TUMOR STAGE": "T4N1bM0", "CELL ORIGIN": "Skin metastasis capillitium", "BRAF": "wt"}}, {"GSM700750": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M060125", "TUMOR STAGE": "TxNxM1c", "CELL ORIGIN": "Skin metastasis scapula", "BRAF": "V600E"}}, {"GSM70075": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M010119", "TUMOR STAGE": "T2bN3M0", "CELL ORIGIN": "Skin metastasis shoulder", "BRAF": "L597S"}}, {"GSM700752": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M081008", "TUMOR STAGE": "T1aN0M0", "CELL ORIGIN": "Primary face", "BRAF": "wt"}}, {"GSM700753": {"CELL CULTURE PHENOTYPE": "invasive", "NRAS": "wt", "CELL LINE": "M080307", "TUMOR STAGE": "T4N2M1c", "CELL ORIGIN": "Soft tissue metastasis axilla", "BRAF": "wt"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding...", "pubmed_id": 21176117, "geo_gse_id": "E-GEOD-28335", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 6, "sample_count": 12, "tags": ["cell", "disease", "melanoma", "metastatic melanoma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "melanoma-cell-culture-phenotypes", "geo_id_plat": "E-GEOD-28335_A-AFFY-44", "name": "Melanoma cell culture phenotypes", "created": "Sep.16, 2014", "summary": "Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding patients experience disease relapse. We describe here how melanoma cells respond to MAPK inhibition in a phenotype-specific manner, suggesting that slow cycling invasive phenotype cells provide a treatment-resistant pool from which disease relapse may be derived. The implication is that while MAPK inhibition may successfully treat proliferating cells, another cell population needs to be addressed at the same time. 12 samples", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28335", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28335/samples/"}