{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6428, "factors": [{"GSM700733": {"STRAIN OR LINE": "Bcl11a +/+", "VARIATION": "wildtype"}}, {"GSM700733": {"STRAIN OR LINE": "Bcl11a +/+", "VARIATION": "wildtype"}}, {"GSM700733": {"STRAIN OR LINE": "Bcl11a +/+", "VARIATION": "wildtype"}}, {"GSM700736": {"STRAIN OR LINE": "Bcl11a fl/fl EpoR-Cre+", "VARIATION": "BCL11A knockout"}}, {"GSM700736": {"STRAIN OR LINE": "Bcl11a fl/fl EpoR-Cre+", "VARIATION": "BCL11A knockout"}}, {"GSM700736": {"STRAIN OR LINE": "Bcl11a fl/fl EpoR-Cre+", "VARIATION": "BCL11A knockout"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo...", "pubmed_id": 21998251, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 6, "tags": ["bone", "hemoglobin"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-28333_A-AFFY-45", "slug": "expression-data-from-bcl11a-null-and-wild-type-bon", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28333", "geo_gds_id": "", "name": "Expression data from BCL11A-null and wild-type bone marrow erythroid pregenitors", "created": "Nov.11, 2014", "summary": "BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals. We used microarray to determine the changes in gene expression profile after loss of BCL11A in adult erythroid cells CD71+Ter119+ erythroid progenitor cells were FACS-sorted from bone marrows of 6-week old control (Bcl11a +/+) and BCL11A knockout (Bcl11a fl/fl EpoR-Cre+) mice.", "geo_gse_id": "E-GEOD-28333", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28333/samples/"}