Dataset: Expression data from BCL11A-null and wild-type bone marrow erythroid pregenitors

BCL11A is a critical mediator of hemoglobin switching and gamma-globin silencing. In this study, we showed the BCL11A is required in vivo for developmental silencing of gamma-globin genes in adult animals. We used microarray to determine the changes in gene expression profile after loss of BCL11A in adult erythroid cells CD71+Ter119+ erythroid progenitor cells were FACS-sorted from bone marrows of 6-week old control (Bcl11a +/+) and BCL11A knockout (Bcl11a fl/fl EpoR-Cre+) mice.

Species:

mouse

Samples:

6

Source:

E-GEOD-28333

PubMed:

21998251

Updated:

Dec.12, 2014

Registered:

Nov.11, 2014