{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM69765": {"DISEASE STATE": "HIV-"}}, {"GSM69765": {"DISEASE STATE": "HIV-"}}, {"GSM69765": {"DISEASE STATE": "HIV-"}}, {"GSM697654": {"DISEASE STATE": "HIV+"}}, {"GSM697654": {"DISEASE STATE": "HIV+"}}, {"GSM697654": {"DISEASE STATE": "HIV+"}}], "id": 4015, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene...", "geo_gse_id": "E-GEOD-28177", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cell", "gut", "hiv infection", "longitudinal", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-haart-interruption-in-hiv-pat", "geo_id_plat": "E-GEOD-28177_A-AFFY-44", "name": "Expression data from HAART interruption in HIV patients", "created": "Sep.16, 2014", "summary": "We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. Proviral variants in GALT and peripheral blood mononuclear cells (PBMCs) displayed low levels of genomic diversity at all times. A rapid increase in viral loads with a modest decline of CD4  T cells in peripheral blood was observed, while gut mucosal CD4 T cell loss was severe following HAART interruption. This was accompanied by increased mucosal gene expression regulating interferon (IFN)-mediated antiviral responses and immune activation, a profile similar to those found in HAART-naive HIV-infected patients. Gut mucosal responses to HAART interruption were evaluated with Affymetrix arrays", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28177", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28177/samples/"}