{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM697600": {"TREATMENT": "cultured on highly-aligned electrospun nanofibers of poly-caprolactone"}}, {"GSM697600": {"TREATMENT": "cultured on highly-aligned electrospun nanofibers of poly-caprolactone"}}, {"GSM697600": {"TREATMENT": "cultured on highly-aligned electrospun nanofibers of poly-caprolactone"}}, {"GSM697603": {"TREATMENT": "cultured on randomly-oriented electrospun nanofibers of poly-caprolactone"}}, {"GSM697603": {"TREATMENT": "cultured on randomly-oriented electrospun nanofibers of poly-caprolactone"}}, {"GSM697603": {"TREATMENT": "cultured on randomly-oriented electrospun nanofibers of poly-caprolactone"}}], "id": 4011, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "The goal of this experiment was to compare the gene expression of glioma cells migrating on substrates of different topographies and to...", "geo_gse_id": "E-GEOD-28167", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["glioma"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "topography-dependent-gene-expression-in-migratory", "geo_id_plat": "E-GEOD-28167_A-AFFY-44", "name": "Topography-dependent gene expression in migratory glioma cells", "created": "Sep.15, 2014", "summary": "The goal of this experiment was to compare the gene expression of glioma cells migrating on substrates of different topographies and to determine a migration-associated gene profile. Human malignant glioma U251MG cells were cultured on highly-aligned versus randomly-oriented electrospun nanofibers of poly-caprolactone. Cells migrated actively on aligned nanofibers but motility was very restricted on randomly-oriented fibers. Results of gene expression profiling indicated upregulation of a JAK/STAT signature in actively migrating glioma cells. Total RNA was extracted from 3 independent cultures of U251 glioma cells cultured on aligned versus random nanofibers and applied to Affymetrix HG-U133 plus 2 chips. Analysis of gene expression was used to determine a gene-signature correlated with different substrate topography", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28167", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-28167/samples/"}