{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "rat", "factors": [{"GSM692395": {"PROTOCOL": "sham shock"}}, {"GSM692395": {"PROTOCOL": "sham shock"}}, {"GSM692395": {"PROTOCOL": "sham shock"}}, {"GSM692395": {"PROTOCOL": "sham shock"}}, {"GSM692399": {"PROTOCOL": "T/HS with resuscitation with IL6"}}, {"GSM692400": {"PROTOCOL": "T/HS with resuscitation with PBS"}}, {"GSM692400": {"PROTOCOL": "T/HS with resuscitation with PBS"}}, {"GSM692399": {"PROTOCOL": "T/HS with resuscitation with IL6"}}, {"GSM692400": {"PROTOCOL": "T/HS with resuscitation with PBS"}}, {"GSM692400": {"PROTOCOL": "T/HS with resuscitation with PBS"}}, {"GSM692399": {"PROTOCOL": "T/HS with resuscitation with IL6"}}, {"GSM692406": {"PROTOCOL": "GQ-ODN pre-treatment followed by T/HS with resuscitation with IL6"}}, {"GSM692406": {"PROTOCOL": "GQ-ODN pre-treatment followed by T/HS with resuscitation with IL6"}}, {"GSM692406": {"PROTOCOL": "GQ-ODN pre-treatment followed by T/HS with resuscitation with IL6"}}, {"GSM692399": {"PROTOCOL": "T/HS with resuscitation with IL6"}}], "id": 9528, "pop_total": 0, "platform": 13, "summary_wrapped": "We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of...", "geo_gse_id": "E-GEOD-27978", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 15, "tags": ["liver"], "lastmodified": "Jun.26, 2015", "is_default": false, "geo_id_plat": "E-GEOD-27978_A-AFFY-25", "slug": "il-6-mediated-activation-of-stat3-prevents-traumah", "geo_gds_id": "", "name": "IL-6-mediated activation of STAT3\u03b1 prevents trauma/hemorrhagic shock-induced liver inflammation", "created": "Jan.12, 2015", "summary": "We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS and the effect of IL-6 on this model with and without pharmacologic blockade of Stat3-mediated IL-6 and identified distinct members of the inflammasome de-regulated  during T/HS that normalized with IL-6 administration during resuscitation. Adult male rats were subjected to either sham procedure, a trauma plus hemorrhagic shock (T/HS) procedure, T/HS with IL-6 versus PBS during resuscitation, or pretreatment with pharmacologic blockade of Stat3-mediated IL6 via GQ-ODN and after procedural completion, animals were sacrificed and livers were taken and homegenized for RNA extraction and microarray analysis using Affymetrix Rat 230A GeneChip\u00ae array", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27978", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27978/samples/"}