{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM688863": {"GENOTYPE": "HDAC6 knock out"}}, {"GSM688863": {"GENOTYPE": "HDAC6 knock out"}}, {"GSM688863": {"GENOTYPE": "HDAC6 knock out"}}, {"GSM688866": {"GENOTYPE": "Wild type"}}, {"GSM688866": {"GENOTYPE": "Wild type"}}, {"GSM688866": {"GENOTYPE": "Wild type"}}], "id": 8539, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and...", "pubmed_id": 21444725, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["chromatin", "colitis", "histone", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "hdac6-and-hsp90-control-the-functions-of-foxp3-t-r", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27896", "geo_id_plat": "E-GEOD-27896_A-AFFY-36", "name": "HDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells", "created": "Nov.24, 2014", "summary": "Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC inhibitors developed for oncology enhance Treg production and suppression but have limited non-oncologic applications given their broad effects. We show, using HDAC6-deficient mice and WT mice treated with HDAC6-specific inhibitors, that HDAC6 inhibition promotes Treg suppressive activity in models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully MHC-incompatible cardiac allograft rejection. Many of the beneficial effects of HDAC6 targeting are also achieved by inhibition of the HDAC6-regulated protein, HSP90. Hence, selective targeting of a single HDAC isoform, HDAC6, or its downstream target, HSP90, can promote Treg-dependent suppression of autoimmunity and transplant rejection. RNA from three independent samples from magnetically separated CD4+CD25+ Treg of HDAC6 knock out, compared to wild type (C57BL6) control", "geo_gse_id": "E-GEOD-27896", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27896/samples/"}