{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM686327": {"GENOTYPE/VARIATION": "KrasTgfbr2-/-"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686328": {"GENOTYPE/VARIATION": "KrasTgfbr2 wt"}}, {"GSM686327": {"GENOTYPE/VARIATION": "KrasTgfbr2-/-"}}, {"GSM686327": {"GENOTYPE/VARIATION": "KrasTgfbr2-/-"}}, {"GSM686327": {"GENOTYPE/VARIATION": "KrasTgfbr2-/-"}}, {"GSM686327": {"GENOTYPE/VARIATION": "KrasTgfbr2-/-"}}], "id": 6389, "pop_total": 0, "platform": 6, "summary_wrapped": "Recent data suggests that repression of the Type II TGF-B Receptor (Tgfr2) repression in human lung adenocarcinoma is important for...", "geo_gse_id": "E-GEOD-27717", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 11, "tags": ["adenocarcinoma", "cancer", "lung", "lung adenocarcinoma", "lung cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-27717_A-AFFY-45", "slug": "expression-data-from-lung-tumors-of-krastgfbr2-mou", "geo_gds_id": "", "name": "Expression data from lung tumors of KrasTgfbr2 -/- mouse model", "created": "Nov.11, 2014", "summary": "Recent data suggests that repression of the Type II TGF-B Receptor (Tgfr2) repression in human lung adenocarcinoma is important for progression from noninvasive to invasive adenocarcinoma. To test this hypothesis in a animal model of non-invasive lung cancer, we generated an inducible, lung specific Tgfbr2 knockout model in the oncogenic Kras mouse. LSL-KrasG12D positive mice were simultaneously backcrossed to C57/Bl6 mice and to the Tgfbr2 flox/flox mice. To induce tumors, 100 _l of saline containing 3x10e10 particles of an adenovirus containing the Cre recombinase (Ad.Cre) was administered to each LSL-KrasG12D mouse intra-nasally. Mice were sacrificed at 7 weeks after administration of Adeno-Cre.  We used laser capture microdissection to acquire tumor cells from KrasTgfbr2-/-  and KrasTgfbr2 wt mouse tumors.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27717", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27717/samples/"}