ArrayExpress Uploader0human1afemaleBronchioloAlveolar Carcinoma068Ia2amaleAdenoCarcinoma-mixed invasive071Ib1afemaleBronchioloAlveolar Carcinoma071Ia1amaleBronchioloAlveolar Carcinoma074Ia2afemaleAdenoCarcinoma-mixed invasive080Ib1bfemaleBronchioloAlveolar Carcinoma086Ia1afemaleAdenoCarcinoma-mixed invasive065Ia1afemaleBronchioloAlveolar Carcinoma070Ia1bmaleAdenoCarcinoma-mixed invasive278IIIa2amaleAdenoCarcinoma-mixed invasive063Ib1afemaleAdenoCarcinoma-mixed invasive074Ia1amaleAdenoCarcinoma-mixed invasive073Ia2amaleAdenoCarcinoma-mixed invasive161IIa3femaleBronchioloAlveolar Carcinoma075IIb1afemaleAdenoCarcinoma-mixed invasive067Ia1afemaleBronchioloAlveolar Carcinoma067Ia1amaleAdenoCarcinoma-mixed invasive070Ia1amaleAdenoCarcinoma-mixed invasive066Ia1bfemaleAdenoCarcinoma-mixed invasive070Ia1afemaleBronchioloAlveolar Carcinoma053Ia1afemaleBronchioloAlveolar Carcinoma072Ia2afemaleAdenoCarcinoma-mixed invasive057Ib1afemaleBronchioloAlveolar Carcinoma067Ia1bfemaleAdenoCarcinoma-mixed invasive079Ia3femaleBronchioloAlveolar Carcinoma073IIb1afemaleAdenoCarcinoma-mixed invasive061Ia2afemaleAdenoCarcinoma-mixed invasive065Ib1afemaleAdenoCarcinoma-mixed invasive261IIIa2amaleAdenoCarcinoma-mixed invasive059Ib1afemaleBronchioloAlveolar Carcinoma082Ia1amaleBronchioloAlveolar Carcinoma090Ia2afemaleAdenoCarcinoma-mixed invasive088Ib2afemaleAdenoCarcinoma-mixed invasive262IIIa2afemaleAdenoCarcinoma-mixed invasive259IIIa2afemaleBronchioloAlveolar Carcinoma059Ib1afemaleBronchioloAlveolar Carcinoma064Ia1bfemaleBronchioloAlveolar Carcinoma073Ia4femaleAdenoCarcinoma-mixed invasive063IIIa2afemaleAdenoCarcinoma-mixed invasive057Ib1afemaleBronchioloAlveolar Carcinoma055Ia3987arrayexpress_sid4The World Health Organization has subclassified adenocarcinoma based upon predominant cell morphology and growth pattern such as...E-GEOD-27716/profile/8773/arrayexpressuploader640adenocarcinomacarcinomacellcell morphologylunglung adenocarcinomaDec.12, 2014Falseexpression-data-from-columbia-lung-adenocarcinomaE-GEOD-27716_A-AFFY-44Expression data from Columbia Lung Adenocarcinoma Human Tumor CellsSep.15, 2014The World Health Organization has subclassified adenocarcinoma based upon predominant cell morphology and growth pattern such as bronchioloalveolar carcinoma (BAC), adenocarcinoma with mixed subtypes (AC-mixed), and homogenously invasive tumors with a variety of histological patterns Pure invasive adenocarcinomas are often devoid of bronchioloalveolar morphology. The clinical importance of lung adenocarcinoma invasion is supported by several recent studies indicating that the risk of death in non-mucinous BAC is significantly lower than that of pure invasive tumors and in tumors with greater than 0.6 cm of fibrosis or linear invasion (J Thorac Oncol 6:244-285) To identify human tumor cell signatures associated with lung adenocarcinoma subtype and invasion, we performed microarray gene expression profiling of microdissected tumor cells noninvasive AC and AC-Mixed invasive tumors. 17 cases of noninvasive AC tumors and 23 cases of AC-mixed subtype invasive lung adenocarcinomas resected from 2002 to 2006 were examined (Columbia Lung Adenocarcinoma dataset)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27716http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27716/samples/