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Home › Dataset Library › Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell...

Dataset: Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell aging

Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a...

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Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understand the aging process. Using a model that carries a proofreading defective mitochondrial DNA polymerase, we demonstrate hematopoietic defects reminiscent of premature HSC aging including anemia, lymphopenia and myeloid lineage skewing. However, in contrast to physiologic stem cell aging, rapidly accumulating mitochondrial DNA mutations displayed little involvement of the hematopoietic stem cell pool but rather with distinct differentiation blocks and/or disappearance of downstream progenitors. Hematopoietic stem cells (HSC) has been sorted out from midaged wildtype and mutator mice and compared with stem cells sorted from young and and old wt mice

Species:
mouse

Samples:
16

Source:
E-GEOD-27686

PubMed:
21549326

Updated:
Dec.12, 2014

Registered:
Nov.11, 2014


Factors: (via ArrayExpress)
Sample AGE GENOTYPE
GSM685745 24 months wild type
GSM685745 24 months wild type
GSM685745 24 months wild type
GSM685748 9-12 weeks wild type
GSM685749 9-12 weeks
GSM685749 9-12 weeks
GSM68575 32 weeks Polgtm1Lrsn-/-
GSM68575 32 weeks Polgtm1Lrsn-/-
GSM68575 32 weeks Polgtm1Lrsn-/-
GSM685754 32 weeks Polgtm1Lrsn+/+
GSM685754 32 weeks Polgtm1Lrsn+/+
GSM685754 32 weeks Polgtm1Lrsn+/+
GSM685757 8-12 weeks wild type
GSM685757 8-12 weeks wild type
GSM685757 8-12 weeks wild type
GSM685757 8-12 weeks wild type

Tags

  • anemia
  • cell
  • lymphopenia
  • stem cell

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