ArrayExpress Uploader0mouseLSL-KrasG12D x C57/Bl6stromaKrasTgfbr2wtLSL-KrasG12D x C57/Bl6stromaKrasTgfbr2wtLSL-KrasG12D x C57/Bl6stromaKrasTgfbr2wtLSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxstromaKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxstromaKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxstromaKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxstromaKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6lung tumorKrasTgfbr2wtLSL-KrasG12D x C57/Bl6lung tumorKrasTgfbr2wtLSL-KrasG12D x C57/Bl6lung tumorKrasTgfbr2wtLSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxlung tumorKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxlung tumorKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxlung tumorKrasTgfbr2-/-LSL-KrasG12D x C57/Bl6 x Tgfbr2 flox/floxlung tumorKrasTgfbr2-/-6385arrayexpress_sid6Recent data suggests that repression of the Type II TGF-B Receptor (Tgfr2) repression in human lung adenocarcinoma is important for...E-GEOD-27675/profile/8773/arrayexpressuploader314adenocarcinomacancercellcompartmentlunglung adenocarcinomalung cancerstromal cellDec.12, 2014Falseexpression-data-from-lung-tumor-and-stromal-cellsE-GEOD-27675_A-AFFY-45Expression data from lung tumor and stromal cells of KrasTgfbr2 -/- mouse modelNov.11, 2014Recent data suggests that repression of the Type II TGF-B Receptor (Tgfr2) repression in human lung adenocarcinoma is important for progression from noninvasive to invasive adenocarcinoma. To test this hypothesis in a animal model of non-invasive lung cancer, we generated an inducible, lung specific Tgfbr2 knockout model in the oncogenic Kras mouse. LSL-KrasG12D positive mice were simultaneously backcrossed to C57/Bl6 mice and to the Tgfbr2 flox/flox mice. To induce tumors, 100 ul of saline containing 3x10e10 particles of an adenovirus containing the Cre recombinase (Ad.Cre) was administered to each LSL-KrasG12D mouse intra-nasally. We evaluated the tumor microenvironment response to Tgfbr2 deficient tumor cells. We compared lung tumor cell and stromal cell transcriptional profiles from five-week KrasTgfbr2 -/- and nine-week KrasTgfbr2 WT mice. We used mice at these time points to allow comparison of the stromal compartment of similarly advanced tumors.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27675http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27675/samples/