ArrayExpress Uploader0humanB6TCGFP+ and estrogen-independentB6TCGFP+ and estrogen-independentB6TCGFP+ and estrogen-independentMDA231ER negative MDA-MB-231/GFP/Neo cells resistant to G418MDA231ER negative MDA-MB-231/GFP/Neo cells resistant to G418MDA231ER negative MDA-MB-231/GFP/Neo cells resistant to G418ZR75ER positive ZR-75-1/GFP/puroZR75ER positive ZR-75-1/GFP/puroZR75ER positive ZR-75-1/GFP/puro3979arrayexpress_sid4The origin and the contribution of breast tumor heterogeneity to its progression are not clear. We investigated the effect of a growing...E-GEOD-27515/profile/8773/arrayexpressuploader29bonebone marrowbreastbreast tumorcancercellestrogenlineDec.12, 2014Falseisolation-and-characterization-of-a-metastatic-hybE-GEOD-27515_A-AFFY-44Isolation and characterization of a metastatic hybrid cell line generated by ER negative and ER positive breast cancer cells in mouse bone marrowSep.15, 2014The origin and the contribution of breast tumor heterogeneity to its progression are not clear. We investigated the effect of a growing orthotopic tumor formed by an aggressive estrogen receptor (ER)-negative breast cancer cell line on the metastatic potential of a less aggressive ER-positive breast cancer cell line for the elucidation of how the presence of heterogeneous cancer cells might affect each other’s metastatic behavior. ER positive ZR-75-1/GFP/puro cells, resistant to puromycin and non-tumorigenic/non-metastatic without exogenous estrogen supplementation, were injected intracardiacally into mice bearing growing orthotopic tumors, formed by ER negative MDA-MB-231/GFP/Neo cells resistant to G418. A variant cell line B6, containing both estrogen-dependent and -independent cells, were isolated from GFP expressing cells in the bone marrow and re-inoculated in nude mice to generate an estrogen-independent cell line B6TC.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27515http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27515/samples/