{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM677063": {"TISSUE": "lung, lymphocytes"}}, {"GSM677064": {"TISSUE": "bronchial lymphnodes, lymphocytes"}}, {"GSM677064": {"TISSUE": "bronchial lymphnodes, lymphocytes"}}, {"GSM677063": {"TISSUE": "lung, lymphocytes"}}, {"GSM677064": {"TISSUE": "bronchial lymphnodes, lymphocytes"}}, {"GSM677063": {"TISSUE": "lung, lymphocytes"}}], "id": 6366, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Role for naturally occurring CD4+CD25+Foxp3+ regulatory T cells (nTregs) in counterbalancing this process. Using a transgenic murine...", "geo_gse_id": "E-GEOD-27379", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cell", "disease", "influenza", "lung", "lung disease", "lymph", "spleen"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "cd8-t-cell-mediated-lung-inflammation", "geo_id_plat": "E-GEOD-27379_A-AFFY-45", "name": "CD8+ T cell mediated lung inflammation", "created": "Nov.11, 2014", "summary": "Role for naturally occurring CD4+CD25+Foxp3+ regulatory T cells (nTregs) in counterbalancing this process. Using a transgenic murine model for autoimmune-mediated lung disease, we demonstrated that, despite pulmonary inflammation, lung-specific CD8+ T cells can reside quiescently in close proximity to self-antigen. Whereas self-reactive CD8+ T cells in the inflamed lung and lung-draining lymph nodes down-regulated the expression of effector molecules, those located in the spleen appeared to be partly antigen-experienced and displayed a memory-like phenotype. Since ex vivo-reisolated self-reactive CD8+ T cells were very well capable to respond to the antigen in vitro, we investigated a possible contribution of nTregs to the immune control over autoaggressive CD8+ T cells in the lung. We isolated antigen-specifc CD8+ T-cells from lungs and bronchial lymphnodes derived from chronic diseased mice (SPC-HAxCL4), healthy control mice (CL4) and acute influenza infected control mice (CL4+IAV) and perormed mRNA expression profiling of isolated CD8+ T cells. Each group represents a pool of at least n=4 animals. CD8+ T cell type comparison; lung disease state analysis", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27379", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27379/samples/"}