{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6365, "factors": [{"GSM67704": {"TREATMENT": "control"}}, {"GSM67704": {"TREATMENT": "control"}}, {"GSM677043": {"TREATMENT": "dorsomorphin"}}, {"GSM677043": {"TREATMENT": "dorsomorphin"}}, {"GSM677045": {"TREATMENT": "stimulated"}}, {"GSM677045": {"TREATMENT": "stimulated"}}, {"GSM677047": {"TREATMENT": "stimulated and dorsomorphin"}}, {"GSM677047": {"TREATMENT": "stimulated and dorsomorphin"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Dorsomorphin is a small molecule inhibitor of type I bone morphogenic protein receptors (BMPRs). We have found that dorsomorphin affects...", "pubmed_id": 22144105, "geo_gse_id": "E-GEOD-27378", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["bone", "cell", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "differential-effects-of-inhibition-of-bone-morphog", "geo_id_plat": "E-GEOD-27378_A-AFFY-45", "name": "Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation", "created": "Nov.11, 2014", "summary": "Dorsomorphin is a small molecule inhibitor of type I bone morphogenic protein receptors (BMPRs). We have found that dorsomorphin affects a wide range of T cell function. In order to obtain the bigger picture of the effects of DM in T cell activation. transcriptomic analysis was performed using mouse primary CD25-CD4+ T cells with either DM (4 \u03bcM) or vehicle in the presence or absence of stimulation by anti-CD3 and -CD28 antibodies.  Mouse CD4+ T cells were prepared and cultured with or without stimulation by plate bound anti-CD3 mAb and soluble anti-CD28 mAb for 1 hour. Subsequently, 4 \u03bcM DM or DMSO was added and cells were incubated for 6 hours. Total RNA was isolated using Qiagen RNeasy mini kits.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27378", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27378/samples/"}