ArrayExpress Uploader063590000222244446666arrayexpress_sid6Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell...22179924/profile/8773/arrayexpressuploader116cellcolitiscoloncrohn's diseasediseasegenomeDec.12, 2014FalseE-GEOD-27302_A-AFFY-45transcription-profiling-by-array-of-mouse-colon-tihttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27302Transcription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transferNov.11, 2014Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell dependent experimental colitis models have gained prominent favor as useful models to identify potential pathogenic mechanisms. The naïve CD4+CD45Rbhigh cell transfer model into recombinase activating gene-1 deficient (RAG-/-) mice induces both colitis and small bowel inflammation reflecting Crohn's disease with unclear pathogenic mechanisms. Given the pathological similarities between the T cell transfer model of colitis and clinical disease, we sought to identify changes in whole genome expression profiles over time during the delelopment of colitis. Male RAG-1-/- C57BL/6 mice were injected with a half million CD4+CD45RBhigh T cells from healthy wild type C57BL/6 male mice. The colon tissue from individual cohorts were collected at weeks 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymetrix GeneChip Mouse Genome 430 2.0 Array.E-GEOD-27302mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27302/samples/