{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6359, "factors": [{"GSM675083": {"time": 0}}, {"GSM675083": {"time": 0}}, {"GSM675083": {"time": 0}}, {"GSM675083": {"time": 0}}, {"GSM675087": {"time": 2}}, {"GSM675087": {"time": 2}}, {"GSM675087": {"time": 2}}, {"GSM675087": {"time": 2}}, {"GSM67509": {"time": 4}}, {"GSM67509": {"time": 4}}, {"GSM67509": {"time": 4}}, {"GSM67509": {"time": 4}}, {"GSM675095": {"time": 6}}, {"GSM675095": {"time": 6}}, {"GSM675095": {"time": 6}}, {"GSM675095": {"time": 6}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell...", "pubmed_id": 22179924, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 16, "tags": ["cell", "colitis", "colon", "crohn's disease", "disease", "genome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-27302_A-AFFY-45", "slug": "transcription-profiling-by-array-of-mouse-colon-ti", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27302", "geo_gds_id": "", "name": "Transcription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transfer", "created": "Nov.11, 2014", "summary": "Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell dependent experimental colitis models have gained prominent favor as useful models to identify potential pathogenic mechanisms. The na\u00efve CD4+CD45Rbhigh cell transfer model into recombinase activating gene-1 deficient (RAG-/-) mice induces both colitis and small bowel inflammation reflecting Crohn's disease with unclear pathogenic mechanisms. Given the pathological similarities between the T cell transfer model of colitis and clinical disease, we sought to identify changes in whole genome expression profiles over time during the delelopment of colitis. Male RAG-1-/- C57BL/6 mice were injected with a half million CD4+CD45RBhigh T cells from healthy wild type C57BL/6 male mice. The colon tissue from individual cohorts were collected at weeks 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymetrix GeneChip Mouse Genome 430 2.0 Array.", "geo_gse_id": "E-GEOD-27302", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27302/samples/"}