BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by...

Dataset: Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fibroblasts

Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to...

Registered by ArrayExpress Uploader
View Dataset

Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPS cells) obtained by reprogramming SMA patient and his healthy father fibroblasts, and genetically corrected SMA-iPSC obtained converting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms. Microarray technology was used to assess global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 (Prof. J. Thomson's lab) compared to transcriptomic data obtained by corresponding fibroblasts. The microarray data derived from three different individuals: SMA patient, healthy father and control iPS cells (19.9). We analyzed iPSC from SMA patient (n=2), iPS- from healthy father (n=1) and iPS-19.9 from Prof. Thomson's lab (n=3). The expression profile was compared to SMA patient's fibroblasts (n=2) and healthy father's fibroblasts (n=1)

Species:
human

Samples:
9

Source:
E-GEOD-27206

PubMed:
23253609

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample CELL TYPE VARIATION
GSM672189 fibroblasts SMN1D7/+;SMN2+/+
GSM672188 fibroblasts SMN1D7;SMN2+/+
GSM672188 fibroblasts SMN1D7;SMN2+/+
GSM672186 induced pluripotent stem cells (iPS cells) SMN1+/+;SMN2+/+
GSM672186 induced pluripotent stem cells (iPS cells) SMN1+/+;SMN2+/+
GSM672186 induced pluripotent stem cells (iPS cells) SMN1+/+;SMN2+/+
GSM672183 induced pluripotent stem cells (iPS cells) SMN1D7/+;SMN2+/+
GSM672182 induced pluripotent stem cells (iPS cells) SMN1D7;SMN2+/+
GSM672182 induced pluripotent stem cells (iPS cells) SMN1D7;SMN2+/+

Tags

  • disease
  • genetic disorder
  • motor neuron
  • motor neuron disease
  • muscular atrophy
  • neuron
  • spinal muscular atrophy

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2023 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use