ArrayExpress Uploader02593fibroblastsSMN1D7/+;SMN2+/+fibroblastsSMN1D7;SMN2+/+fibroblastsSMN1D7;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1+/+;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1+/+;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1+/+;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1D7/+;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1D7;SMN2+/+induced pluripotent stem cells (iPS cells)SMN1D7;SMN2+/+arrayexpress_sid4Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to...23253609E-GEOD-27206/profile/8773/arrayexpressuploader29diseasegenetic disordermotor neuronmotor neuron diseasemuscular atrophyneuronspinal muscular atrophyDec.12, 2014Falseglobal-gene-expression-profiles-of-ipsc-from-sma-pE-GEOD-27206_A-AFFY-44Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fibroblastsJul.12, 2014Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPS cells) obtained by reprogramming SMA patient and his healthy father fibroblasts, and genetically corrected SMA-iPSC obtained converting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms. Microarray technology was used to assess global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 (Prof. J. Thomson's lab) compared to transcriptomic data obtained by corresponding fibroblasts. The microarray data derived from three different individuals: SMA patient, healthy father and control iPS cells (19.9). We analyzed iPSC from SMA patient (n=2), iPS- from healthy father (n=1) and iPS-19.9 from Prof. Thomson's lab (n=3). The expression profile was compared to SMA patient's fibroblasts (n=2) and healthy father's fibroblasts (n=1)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27206humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-27206/samples/