{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6344, "factors": [{"GSM662788": {"CELL SOURCE": "Idiotype-specific TCR-transgenic SCID mice injected with MOPC315-containing Matrigel", "CELL PHENOTYPE": "tumoricidal"}}, {"GSM662788": {"CELL SOURCE": "Idiotype-specific TCR-transgenic SCID mice injected with MOPC315-containing Matrigel", "CELL PHENOTYPE": "tumoricidal"}}, {"GSM662788": {"CELL SOURCE": "Idiotype-specific TCR-transgenic SCID mice injected with MOPC315-containing Matrigel", "CELL PHENOTYPE": "tumoricidal"}}, {"GSM66279": {"CELL SOURCE": "TCR-transgenic SCID mice injected with Matrigel containing antigen-loss MOPC315", "CELL PHENOTYPE": "non-tumoricidal"}}, {"GSM66279": {"CELL SOURCE": "TCR-transgenic SCID mice injected with Matrigel containing antigen-loss MOPC315", "CELL PHENOTYPE": "non-tumoricidal"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and...", "pubmed_id": 21407206, "geo_gse_id": "E-GEOD-26912", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 5, "tags": ["b-cell lymphoma", "cancer", "cell", "immune system", "interleukin", "lymphoma", "myeloma", "scid"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "inflammation-driven-by-tumor-specific-th1-cells-pr", "geo_id_plat": "E-GEOD-26912_A-AFFY-45", "name": "Inflammation driven by tumor-specific Th1 cells protects against B-cell cancer", "created": "Nov.11, 2014", "summary": "The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered tumor-promoting. In contrast, the exact nature of protective antitumor immunity remains obscure. In this study, we have quantified locally secreted cytokines during primary immune responses against myeloma and B-cell lymphoma in mice. Strikingly, successful cancer immunosurveillance mediated by tumor-specific CD4+ T cells was consistently associated with elevated local levels of both proinflammatory (IL-1aplha, IL-1beta, and IL-6) and T helper 1 (Th1)-associated cytokines (interferon-alpha, IL-2, IL-12). Cancer eradication was achieved by a collaboration between tumor-specific Th1 cells and tumor-infiltrating, antigen-presenting macrophages. Th1 cells induced secretion of IL-1? and IL-6 by macrophages. Th1-derived interferon-? was shown to render macrophages directly cytotoxic to cancer cells, and to induce macrophages to secrete the angiostatic chemokines CXCL9/MIG and CXCL10/IP-10. Thus, inflammation, when driven by tumor-specific Th1 cells, may prevent rather than promote cancer. Tumoricidal macrophages were isolated from Idiotype-specific TCR-transgenic SCID mice injected with MOPC315-containing Matrigel. Control macrophages were obtained from TCR-transgenic SCID mice injected with Matrigel containing antigen-loss MOPC315.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26912", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26912/samples/"}