{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3942, "factors": [{"GSM662182": {"PHENOTYPE OF THE CELLS": "CXCR1-CD27-CD28-", "INDIVIDUAL NUMBER": "U13"}}, {"GSM662183": {"PHENOTYPE OF THE CELLS": "CXCR1+CD27-CD28-", "INDIVIDUAL NUMBER": "U13"}}, {"GSM662190": {"PHENOTYPE OF THE CELLS": "CXCR1-CD27-CD28-", "INDIVIDUAL NUMBER": "U14"}}, {"GSM662212": {"PHENOTYPE OF THE CELLS": "CXCR1+CD27-CD28-", "INDIVIDUAL NUMBER": "U14"}}, {"GSM662213": {"PHENOTYPE OF THE CELLS": "CXCR1-CD27-CD28-", "INDIVIDUAL NUMBER": "U25"}}, {"GSM662214": {"PHENOTYPE OF THE CELLS": "CXCR1+CD27-CD28-", "INDIVIDUAL NUMBER": "U25"}}, {"GSM662215": {"PHENOTYPE OF THE CELLS": "CXCR1-CD27-CD28-", "INDIVIDUAL NUMBER": "U36"}}, {"GSM662216": {"PHENOTYPE OF THE CELLS": "CXCR1+CD27-CD28-", "INDIVIDUAL NUMBER": "U36"}}, {"GSM662217": {"PHENOTYPE OF THE CELLS": "CXCR1-CD27-CD28-", "INDIVIDUAL NUMBER": "U46"}}, {"GSM662218": {"PHENOTYPE OF THE CELLS": "CXCR1+CD27-CD28-", "INDIVIDUAL NUMBER": "U46"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Effector CD8+ T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector...", "pubmed_id": 22174157, "geo_gse_id": "E-GEOD-26890", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 10, "tags": ["cell", "il-7r"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "gene-expression-profiles-of-human-effector-cd8-t-c", "geo_id_plat": "E-GEOD-26890_A-AFFY-44", "name": "Gene expression profiles of human effector CD8+ T cell subsets", "created": "Sep.15, 2014", "summary": "Effector CD8+ T cells are believed to be terminally differentiated cells having cytotoxic activity and the ability to produce effector cytokines such as INF-\u03b3 and TNF-\u03b1. We investigated the difference between CXCR1+ and CXCR1- subsets of human effector CD27-CD28-CD8+ T cells.  Both subsets similarly expressed cytolytic molecules and exerted substantial cytolytic activity, whereas only the CXCR1- subset had IL-2 productivity and self-proliferative activity and was more resistant to cell death than the CXCR1+ subset.  These differences were explained by the specific up-regulation of CAMK4, SPRY2, and IL-7R in the CXCR1- subset and that of pro-apoptotic DAPK1 in the CXCR1+ subset.  The IL-2 producers were more frequently found in the IL-7R+ subset of the CXCR1- effector CD8+ T cells than in the IL-7R- subset.  IL-7/IL-7R signaling promoted cell survival only in the CXCR1- subset.  The present study has highlighted a novel subset of effector CD8+ T cells producing IL-2 and suggests the importance of this subset in the homeostasis of effector CD8+ T cells. To find the genes that potentially cause the difference in IL-2 productivity and cell survival between the CXCR1+ and CXCR1- human effector CD8+ T cell subsets, we performed microarray gene expression analysis.  We highly purified each CD3+CD8+ subset for this analysis (> 95.3%) from 5 healthy individuals, and then compared the gene expression profiles of each subset.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26890", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26890/samples/"}