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Home › Dataset Library › A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer

Dataset: A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer

To identify a prognostic gene signature accounting for the distinct clinical outcomes in ovarian cancer patients Despite the existence of...

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To identify a prognostic gene signature accounting for the distinct clinical outcomes in ovarian cancer patients Despite the existence of morphologically indistinguishable disease, patients with advanced ovarian tumors display a broad range of survival end points. We hypothesize that gene expression profiling can identify a prognostic signature accounting for these distinct clinical outcomes. To resolve survival-associated loci, gene expression profiling was completed for an extensive set of 185(90 optimal/95 suboptimal) primary ovarian tumors using the Affymetrix human U133A microarray. Cox regression analysis identified probe sets associated with survival in optimally and suboptimally debulked tumor sets at a P value of <0.01. Leave-one-out cross-validation was applied to each tumor cohort and confirmed by a permutation test. External validation was conducted by applying the gene signature to a publicly available array database of expression profiles of advanced stage suboptimally debulked tumors. The prognostic signature successfully classified the tumors according to survival for suboptimally (P = 0.0179) but not optimally debulked (P = 0.144) patients. The suboptimal gene signature was validated using the independent set of tumors (odds ratio, 8.75; P = 0.0146). To elucidate signaling events amenable to therapeutic intervention in suboptimally debulked patients, pathway analysis was completed for the top 57 survival-associated probe sets. For suboptimally debulked patients, confirmation of the predictive gene signature supports the existence of a clinically relevant predictor, as well as the possibility of novel therapeutic opportunities. Ultimately, the prognostic classifier defined for suboptimally debulked tumors may aid in the classification and enhancement of patient outcome for this high-risk population. Gene expression profiling was completed for an extensive set of 185 primary ovarian tumors and 10 normal ovarian surface epithelium using the Affymetrix human U133A microarray

Species:
human

Samples:
195

Source:
E-GEOD-26712

Updated:
Dec.12, 2014

Registered:
Jun.24, 2014


Factors: (via ArrayExpress)
Sample STATUS SURVIVAL YEARS TISSUE SURGERY OUTCOME
GSM657713 DOD (dead of disease) 3.73 Late-stage high-grade ovarian cancer Suboptimal
GSM657712 NED (no evidence of disease) 4.63 Late-stage high-grade ovarian cancer Optimal
GSM6577 AWD (alive with disease) 4.66 Late-stage high-grade ovarian cancer Suboptimal
GSM657710 NED (no evidence of disease) 4.76 Late-stage high-grade ovarian cancer Suboptimal
GSM657709 NED (no evidence of disease) 4.74 Late-stage high-grade ovarian cancer Optimal
GSM657708 AWD (alive with disease) 4.96 Late-stage high-grade ovarian cancer Suboptimal
GSM657707 DOD (dead of disease) 0.74 Late-stage high-grade ovarian cancer Suboptimal
GSM657706 DOD (dead of disease) 1.12 Late-stage high-grade ovarian cancer Suboptimal
GSM657705 NED (no evidence of disease) 4.9 Late-stage high-grade ovarian cancer Suboptimal
GSM657704 DOD (dead of disease) 1.81 Late-stage high-grade ovarian cancer Suboptimal
GSM657703 AWD (alive with disease) 4.46 Late-stage high-grade ovarian cancer Optimal
GSM657702 AWD (alive with disease) 7.97 Late-stage high-grade ovarian cancer Optimal
GSM65770 NED (no evidence of disease) 4.89 Late-stage high-grade ovarian cancer Suboptimal
GSM657700 DOD (dead of disease) 3.94 Late-stage high-grade ovarian cancer Optimal
GSM657699 DOD (dead of disease) 0.71 Late-stage high-grade ovarian cancer Suboptimal
GSM657698 NED (no evidence of disease) 4.88 Late-stage high-grade ovarian cancer Suboptimal
GSM657697 DOD (dead of disease) 0.52 Late-stage high-grade ovarian cancer Optimal
GSM657696 AWD (alive with disease) 5.27 Late-stage high-grade ovarian cancer Suboptimal
GSM657695 DOD (dead of disease) 4.67 Late-stage high-grade ovarian cancer Suboptimal
GSM657694 DOD (dead of disease) 2.54 Late-stage high-grade ovarian cancer Suboptimal
GSM657693 DOD (dead of disease) 5.4 Late-stage high-grade ovarian cancer Optimal
GSM657692 DOD (dead of disease) 4.55 Late-stage high-grade ovarian cancer Suboptimal
GSM65769 NED (no evidence of disease) 5.43 Late-stage high-grade ovarian cancer Optimal
GSM657690 DOD (dead of disease) 0.79 Late-stage high-grade ovarian cancer Suboptimal
GSM657689 DOD (dead of disease) 6.54 Late-stage high-grade ovarian cancer Optimal
GSM657688 DOD (dead of disease) 6.49 Late-stage high-grade ovarian cancer Suboptimal
GSM657687 NED (no evidence of disease) 5.8 Late-stage high-grade ovarian cancer Optimal
GSM657686 DOD (dead of disease) 5.63 Late-stage high-grade ovarian cancer Suboptimal
GSM657685 DOD (dead of disease) 6.88 Late-stage high-grade ovarian cancer Suboptimal
GSM657684 DOD (dead of disease) 0.56 Late-stage high-grade ovarian cancer Suboptimal
GSM657683 DOD (dead of disease) 2.25 Late-stage high-grade ovarian cancer Suboptimal
GSM657682 DOD (dead of disease) 8.82 Late-stage high-grade ovarian cancer Suboptimal
GSM65768 DOD (dead of disease) 2.18 Late-stage high-grade ovarian cancer Suboptimal
GSM657680 DOD (dead of disease) 2.03 Late-stage high-grade ovarian cancer Optimal
GSM657679 DOD (dead of disease) 0.8 Late-stage high-grade ovarian cancer Suboptimal
GSM657678 DOD (dead of disease) 0.88 Late-stage high-grade ovarian cancer Suboptimal
GSM657677 DOD (dead of disease) 1.66 Late-stage high-grade ovarian cancer Suboptimal
GSM657676 DOD (dead of disease) 1.84 Late-stage high-grade ovarian cancer Suboptimal
GSM657675 DOD (dead of disease) 6.81 Late-stage high-grade ovarian cancer Optimal
GSM657674 DOD (dead of disease) 1.37 Late-stage high-grade ovarian cancer Suboptimal
GSM657673 NED (no evidence of disease) 11.59 Late-stage high-grade ovarian cancer Optimal
GSM657672 NED (no evidence of disease) 11.78 Late-stage high-grade ovarian cancer Suboptimal
GSM65767 DOD (dead of disease) 8.46 Late-stage high-grade ovarian cancer Suboptimal
GSM657670 DOD (dead of disease) 10.87 Late-stage high-grade ovarian cancer Optimal
GSM657669 DOD (dead of disease) 2.33 Late-stage high-grade ovarian cancer Optimal
GSM657668 DOD (dead of disease) 7.43 Late-stage high-grade ovarian cancer Suboptimal
GSM657667 AWD (alive with disease) 10.73 Late-stage high-grade ovarian cancer Optimal
GSM657666 DOD (dead of disease) 5.41 Late-stage high-grade ovarian cancer Suboptimal
GSM657665 DOD (dead of disease) 7.22 Late-stage high-grade ovarian cancer Optimal
GSM657664 DOD (dead of disease) 0.4 Late-stage high-grade ovarian cancer Suboptimal
GSM657663 DOD (dead of disease) 4.88 Late-stage high-grade ovarian cancer Suboptimal
GSM657662 DOD (dead of disease) 5.9 Late-stage high-grade ovarian cancer Suboptimal
GSM65766 DOD (dead of disease) 3.19 Late-stage high-grade ovarian cancer Optimal
GSM657660 DOD (dead of disease) 0.82 Late-stage high-grade ovarian cancer Suboptimal
GSM657659 NED (no evidence of disease) 6.32 Late-stage high-grade ovarian cancer Suboptimal
GSM657658 DOD (dead of disease) 1.98 Late-stage high-grade ovarian cancer Optimal
GSM657657 DOD (dead of disease) 2.53 Late-stage high-grade ovarian cancer Optimal
GSM657656 DOD (dead of disease) 3.74 Late-stage high-grade ovarian cancer Optimal
GSM657655 DOD (dead of disease) 2.62 Late-stage high-grade ovarian cancer Optimal
GSM657654 AWD (alive with disease) 13.5 Late-stage high-grade ovarian cancer Optimal
GSM657653 AWD (alive with disease) 13.46 Late-stage high-grade ovarian cancer Suboptimal
GSM657652 NED (no evidence of disease) 13.65 Late-stage high-grade ovarian cancer Suboptimal
GSM65765 DOD (dead of disease) 1.97 Late-stage high-grade ovarian cancer Suboptimal
GSM657650 DOD (dead of disease) 2.57 Late-stage high-grade ovarian cancer Suboptimal
GSM657649 DOD (dead of disease) 1.1 Late-stage high-grade ovarian cancer Suboptimal
GSM657648 DOD (dead of disease) 9.02 Late-stage high-grade ovarian cancer Suboptimal
GSM657647 DOD (dead of disease) 1.34 Late-stage high-grade ovarian cancer Optimal
GSM657646 DOD (dead of disease) 3.68 Late-stage high-grade ovarian cancer Optimal
GSM657645 DOD (dead of disease) 0.59 Late-stage high-grade ovarian cancer Suboptimal
GSM657644 AWD (alive with disease) 10.04 Late-stage high-grade ovarian cancer Suboptimal
GSM657643 DOD (dead of disease) 1.48 Late-stage high-grade ovarian cancer Optimal
GSM657642 NED (no evidence of disease) 10.09 Late-stage high-grade ovarian cancer Suboptimal
GSM65764 DOD (dead of disease) 0.82 Late-stage high-grade ovarian cancer Optimal
GSM657640 DOD (dead of disease) 1.69 Late-stage high-grade ovarian cancer Suboptimal
GSM657639 DOD (dead of disease) 3.97 Late-stage high-grade ovarian cancer Optimal
GSM657638 DOD (dead of disease) 3.95 Late-stage high-grade ovarian cancer Suboptimal
GSM657637 DOD (dead of disease) 0.97 Late-stage high-grade ovarian cancer Suboptimal
GSM657636 DOD (dead of disease) 1.47 Late-stage high-grade ovarian cancer Optimal
GSM657635 DOD (dead of disease) 2.74 Late-stage high-grade ovarian cancer Optimal
GSM657634 NED (no evidence of disease) 8.12 Late-stage high-grade ovarian cancer Optimal
GSM657633 DOD (dead of disease) 6.51 Late-stage high-grade ovarian cancer Optimal
GSM657632 DOD (dead of disease) 3.55 Late-stage high-grade ovarian cancer Optimal
GSM65763 AWD (alive with disease) 4.39 Late-stage high-grade ovarian cancer Suboptimal
GSM657630 DOD (dead of disease) 7.85 Late-stage high-grade ovarian cancer Optimal
GSM657629 DOD (dead of disease) 2.89 Late-stage high-grade ovarian cancer Optimal
GSM657628 DOD (dead of disease) 0.35 Late-stage high-grade ovarian cancer Suboptimal
GSM657627 DOD (dead of disease) 0.31 Late-stage high-grade ovarian cancer Suboptimal
GSM657626 DOD (dead of disease) 3.99 Late-stage high-grade ovarian cancer Optimal
GSM657625 DOD (dead of disease) 1.56 Late-stage high-grade ovarian cancer Suboptimal
GSM657624 DOD (dead of disease) 4.12 Late-stage high-grade ovarian cancer Suboptimal
GSM657623 DOD (dead of disease) 4.83 Late-stage high-grade ovarian cancer Optimal
GSM657622 DOD (dead of disease) 1.55 Late-stage high-grade ovarian cancer Optimal
GSM65762 DOD (dead of disease) 2.99 Late-stage high-grade ovarian cancer Suboptimal
GSM657620 NED (no evidence of disease) 0.36 Late-stage high-grade ovarian cancer Optimal
GSM657619 DOD (dead of disease) 0.06 Late-stage high-grade ovarian cancer Suboptimal
GSM657618 DOD (dead of disease) 3.24 Late-stage high-grade ovarian cancer Suboptimal
GSM657617 DOD (dead of disease) 3.5 Late-stage high-grade ovarian cancer Optimal
GSM657616 DOD (dead of disease) 2.32 Late-stage high-grade ovarian cancer Suboptimal
GSM657615 DOD (dead of disease) 0.66 Late-stage high-grade ovarian cancer Suboptimal
GSM657614 DOD (dead of disease) 2.4 Late-stage high-grade ovarian cancer Suboptimal
GSM657613 DOD (dead of disease) 0.92 Late-stage high-grade ovarian cancer Suboptimal
GSM657612 DOD (dead of disease) 4.53 Late-stage high-grade ovarian cancer Optimal
GSM6576 DOD (dead of disease) 2.52 Late-stage high-grade ovarian cancer Optimal
GSM657610 DOD (dead of disease) 3.75 Late-stage high-grade ovarian cancer Suboptimal
GSM657609 DOD (dead of disease) 9.22 Late-stage high-grade ovarian cancer Optimal
GSM657608 DOD (dead of disease) 1.3 Late-stage high-grade ovarian cancer Suboptimal
GSM657607 DOD (dead of disease) 0.33 Late-stage high-grade ovarian cancer Suboptimal
GSM657606 DOD (dead of disease) 3.93 Late-stage high-grade ovarian cancer Suboptimal
GSM657605 DOD (dead of disease) 7.88 Late-stage high-grade ovarian cancer Suboptimal
GSM657604 DOD (dead of disease) 0.98 Late-stage high-grade ovarian cancer Suboptimal
GSM657603 DOD (dead of disease) 1.72 Late-stage high-grade ovarian cancer Suboptimal
GSM657602 DOD (dead of disease) 2.2 Late-stage high-grade ovarian cancer Suboptimal
GSM65760 DOD (dead of disease) 1.94 Late-stage high-grade ovarian cancer Suboptimal
GSM657600 DOD (dead of disease) 8.64 Late-stage high-grade ovarian cancer Suboptimal
GSM657617 DOD (dead of disease) 3.5 Late-stage high-grade ovarian cancer Optimal
GSM657598 DOD (dead of disease) 6.83 Late-stage high-grade ovarian cancer Suboptimal
GSM657597 DOD (dead of disease) 5.34 Late-stage high-grade ovarian cancer Suboptimal
GSM657596 DOD (dead of disease) 3.95 Late-stage high-grade ovarian cancer Optimal
GSM657595 DOD (dead of disease) 0.99 Late-stage high-grade ovarian cancer Suboptimal
GSM657594 NED (no evidence of disease) 13.1 Late-stage high-grade ovarian cancer Optimal
GSM657593 DOD (dead of disease) 0.21 Late-stage high-grade ovarian cancer Suboptimal
GSM657592 DOD (dead of disease) 3.12 Late-stage high-grade ovarian cancer Suboptimal
GSM657645 DOD (dead of disease) 0.59 Late-stage high-grade ovarian cancer Suboptimal
GSM657590 NED (no evidence of disease) 13.5 Late-stage high-grade ovarian cancer Optimal
GSM657589 DOD (dead of disease) 0.62 Late-stage high-grade ovarian cancer Suboptimal
GSM657588 DOD (dead of disease) 5.15 Late-stage high-grade ovarian cancer Optimal
GSM657587 DOD (dead of disease) 3.64 Late-stage high-grade ovarian cancer Optimal
GSM657586 NED (no evidence of disease) 6.91 Late-stage high-grade ovarian cancer Optimal
GSM657585 DOD (dead of disease) 0.86 Late-stage high-grade ovarian cancer Suboptimal
GSM657584 DOD (dead of disease) 6.75 Late-stage high-grade ovarian cancer Optimal
GSM657583 DOD (dead of disease) 5.68 Late-stage high-grade ovarian cancer Suboptimal
GSM657582 DOD (dead of disease) 8.8 Late-stage high-grade ovarian cancer Optimal
GSM65758 DOD (dead of disease) 3.18 Late-stage high-grade ovarian cancer Suboptimal
GSM657580 DOD (dead of disease) 4.6 Late-stage high-grade ovarian cancer Optimal
GSM657579 DOD (dead of disease) 1.91 Late-stage high-grade ovarian cancer Suboptimal
GSM657578 DOD (dead of disease) 1.75 Late-stage high-grade ovarian cancer Suboptimal
GSM657577 DOD (dead of disease) 2.96 Late-stage high-grade ovarian cancer Suboptimal
GSM657576 DOD (dead of disease) 4.94 Late-stage high-grade ovarian cancer Suboptimal
GSM657575 DOD (dead of disease) 0.56 Late-stage high-grade ovarian cancer Optimal
GSM657574 NED (no evidence of disease) 1.89 Late-stage high-grade ovarian cancer Optimal
GSM657573 DOD (dead of disease) 1.59 Late-stage high-grade ovarian cancer Optimal
GSM657572 AWD (alive with disease) 2.06 Late-stage high-grade ovarian cancer Optimal
GSM65757 AWD (alive with disease) 2.15 Late-stage high-grade ovarian cancer Optimal
GSM657570 DOD (dead of disease) 2.83 Late-stage high-grade ovarian cancer Suboptimal
GSM657569 AWD (alive with disease) 2.16 Late-stage high-grade ovarian cancer Optimal
GSM657568 DOD (dead of disease) 1.28 Late-stage high-grade ovarian cancer Optimal
GSM657567 AWD (alive with disease) 2.23 Late-stage high-grade ovarian cancer Optimal
GSM657566 AWD (alive with disease) 2.27 Late-stage high-grade ovarian cancer Optimal
GSM657565 DOD (dead of disease) 2.16 Late-stage high-grade ovarian cancer Optimal
GSM657564 NED (no evidence of disease) 2.3 Late-stage high-grade ovarian cancer Optimal
GSM657563 AWD (alive with disease) 2.48 Late-stage high-grade ovarian cancer Optimal
GSM657562 NED (no evidence of disease) 2.37 Late-stage high-grade ovarian cancer Optimal
GSM65756 NED (no evidence of disease) 2.43 Late-stage high-grade ovarian cancer Optimal
GSM657560 NED (no evidence of disease) 2.1 Late-stage high-grade ovarian cancer Optimal
GSM657559 DOD (dead of disease) 6.3 Late-stage high-grade ovarian cancer Optimal
GSM657558 DOD (dead of disease) 2.84 Late-stage high-grade ovarian cancer Suboptimal
GSM657557 AWD (alive with disease) 2.71 Late-stage high-grade ovarian cancer Optimal
GSM657556 DOD (dead of disease) 3.83 Late-stage high-grade ovarian cancer Suboptimal
GSM657555 NED (no evidence of disease) 2.93 Late-stage high-grade ovarian cancer Optimal
GSM657554 DOD (dead of disease) 6.29 Late-stage high-grade ovarian cancer Suboptimal
GSM657553 AWD (alive with disease) 3.7 Late-stage high-grade ovarian cancer Suboptimal
GSM657552 DOD (dead of disease) 2.37 Late-stage high-grade ovarian cancer Suboptimal
GSM65755 AWD (alive with disease) 6.86 Late-stage high-grade ovarian cancer Optimal
GSM657550 DOD (dead of disease) 1.47 Late-stage high-grade ovarian cancer Suboptimal
GSM657549 DOD (dead of disease) 0.17 Late-stage high-grade ovarian cancer Suboptimal
GSM657632 DOD (dead of disease) 3.55 Late-stage high-grade ovarian cancer Optimal
GSM657547 DOD (dead of disease) 1.03 Late-stage high-grade ovarian cancer Optimal
GSM657546 NED (no evidence of disease) 2.94 Late-stage high-grade ovarian cancer Optimal
GSM657545 NED (no evidence of disease) 7.33 Late-stage high-grade ovarian cancer Suboptimal
GSM657544 NED (no evidence of disease) 2.82 Late-stage high-grade ovarian cancer Optimal
GSM657543 NED (no evidence of disease) 3.26 Late-stage high-grade ovarian cancer Optimal
GSM657542 DOD (dead of disease) 2.3 Late-stage high-grade ovarian cancer Optimal
GSM65754 NED (no evidence of disease) 3.3 Late-stage high-grade ovarian cancer Optimal
GSM657540 DOD (dead of disease) 0.71 Late-stage high-grade ovarian cancer Optimal
GSM657539 AWD (alive with disease) 3.49 Late-stage high-grade ovarian cancer Suboptimal
GSM657538 AWD (alive with disease) 3.53 Late-stage high-grade ovarian cancer Optimal
GSM657537 AWD (alive with disease) 3.58 Late-stage high-grade ovarian cancer Optimal
GSM657536 DOD (dead of disease) 2.45 Late-stage high-grade ovarian cancer Optimal
GSM657535 NED (no evidence of disease) 3.77 Late-stage high-grade ovarian cancer Optimal
GSM657534 DOD (dead of disease) 2.51 Late-stage high-grade ovarian cancer Optimal
GSM657533 AWD (alive with disease) 3.99 Late-stage high-grade ovarian cancer Optimal
GSM657532 DOD (dead of disease) 1.72 Late-stage high-grade ovarian cancer Optimal
GSM65753 NED (no evidence of disease) 4.38 Late-stage high-grade ovarian cancer Optimal
GSM657530 NED (no evidence of disease) 4.51 Late-stage high-grade ovarian cancer Optimal
GSM657529 AWD (alive with disease) 7.48 Late-stage high-grade ovarian cancer Optimal
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified
GSM657528 not specified not specified Normal ovarian surface epithelium not specified

Tags

  • cancer
  • disease
  • external
  • ovarian cancer
  • surface

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